Highly sensitive photonic crystal optic fiber with annular stomatal arrangement for cervical cancer cell detection

The photonic crystal fiber sensor designed in this paper uses the surface plasmon resonance phenomenon as its basic operating principle. A metal layer is coated over the outside of the sensor to achieve surface plasmon resonance coupling. Finite element analysis is employed to work out design parameters and assess performance. Here, key design parameters such as the gold layer’s thickness and the stomatal diameter are analyzed to identify the optimal design configuration; And defined the tolerance coefficient of design parameters in the actual production process. Next, the performance of the sensor was analyzed. The refractive index was measured in the scope of 1.370 to 1.395 with an interval of 0.005, the sensor demonstrated outstanding sensing capabilities, achieved wavelength sensitivity of 36,000 nm/RIU, a peak amplitude sensitivity of 142.8 RIU^-1, and a resolution of 2.7 × 10^–6 RIU. In the end, the sensor was used to identify the existence of cervical cancer cells and manifested high wavelength sensitivity, which confirms its excellent biosensing capability. Thanks to its uncomplicated structure, acute sensitivity, and exceptional resolution, the sensor devised in this study is highly suitable for a vast array of applications in chemical and biomedical detection.