Pd（II）催化炔烃与4-羟基-3-马来酰亚胺双香豆素的环化：多环的一锅构造

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-11 DOI:10.1021/acs.orglett.5c0097310.1021/acs.orglett.5c00973

Kumud Sharma, Abhilash Sharma, Kashmiri Neog, Nasib Kayastha, Babulal Das and Pranjal Gogoi*,

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引用次数: 0

摘要

证实了Pd（II）催化4-羟基-3-马来酰亚胺双香豆素与炔的级联环反应。这种独特的策略突出了一个有趣的过程，即通过螺旋环化和环化形成碳环和杂环的三个环（三元，五元和六元）。该方法为高收率合成各种香豆素融合的复杂结构提供了一个有吸引力的平台。此外，六个合成的化合物已被单晶x射线衍射分析明确证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pd(II)-Catalyzed Annulation of Alkynes with 4-Hydroxy-3-Maleimidecoumarin: One-Pot Construction of Multiple Rings

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Pd(II)-Catalyzed Annulation of Alkynes with 4-Hydroxy-3-Maleimidecoumarin: One-Pot Construction of Multiple Rings

A Pd(II)-catalyzed cascade annulation of 4-hydroxy-3-maleimidecoumarin with alkynes has been demonstrated. This unique strategy highlights an interesting process for the cascade formation of three rings (three-, five-, and six-membered) of carbocycles and heterocycles through spiro-annulation followed by cyclization. This strategy offers an attractive platform for synthesizing various coumarin-fused complex structures in good yields. Additionally, six synthesized compounds have been unambiguously confirmed by single-crystal X-ray diffraction analysis.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.