用SPECT定量131i放射免疫治疗。

International journal of cancer. Supplement = Journal international du cancer. Supplement Pub Date : 1988-01-01

S J Riggs, A J Green, R H Begent, K D Bagshawe

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引用次数: 0

摘要

在幻影研究和接受131i标记的抗cea治疗剂量的患者中，比较了平面成像和单光子发射计算机断层扫描(SPECT)的定量。在数据重建过程中，采用了SPECT定量衰减校正和康普顿散射校正。两种方法的局限性都通过幻影研究进行了检验，结果表明，在给予治疗剂量的131i标记的抗cea的患者中，实际的SPECT定量可以实现，而且，SPECT似乎给出了更准确的活性浓度估计。

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Quantitation in 131I-radioimmunotherapy using SPECT.

Quantitation from planar imaging and single photon emission computed tomography (SPECT) were compared in phantom studies and in patients receiving therapeutic doses of 131I-labelled anti-CEA. During the reconstruction of the data for SPECT quantitation attenuation correction and a correction for Compton scatter were used. The limitations of both methods were examined using the phantom studies and it was shown that practical SPECT quantitation could be achieved in patients given therapeutic doses of 131I-labelled anti-CEA, and furthermore, that SPECT appeared to give a more accurate estimate of the activity concentration.

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International journal of cancer. Supplement = Journal international du cancer. Supplement

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