从系统生物学的概念来指导大陆楤木根治疗t2dm源性心脏病和糖尿病肾病的关键治疗成分

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-04-22 DOI:10.1016/j.lfs.2025.123635

Ki-Kwang Oh , Seol Hee Song, Jeong Ha Park , Min Ju Kim, Dong Joon Kim, Ki-Tae Suk

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引用次数: 0

摘要

大陆姜（ACKRs）已被视为治疗不同疾病的营养天然资源，包括2型糖尿病（T2DM）及其并发症(心脏病发作；HA，糖尿病肾病；DN)。尽管如此，对t2dm引起的并发症的广泛调查尚未进行。因此，我们采用气相色谱-质谱法（GC-MS）对ackr分子进行鉴定，然后利用化学信息学(相似性集合法；海,SwissTargetPrediction;STP)、生物信息学（STRING、DisGeNET和OMIM）和计算机筛选工具来研究其在T2DM疾病及其并发症中的相应靶点。主要靶点（PPARG和IL6）通过蛋白-蛋白相互作用（PPI）网络被证实，提示PPAR信号通路上的IL6-穿心花内酯、PPARA-Germacrene D、PPARD- Kaurenoic acid、PPARG- Kaurenoic acid、NR1H3- 1-萘丙醇、α-乙烯十氢-5-（羟甲基）-α、2,5,5,8a-五甲基-和FABP4- Kaurenoic acid构象可能发挥拮抗作用。这些发现表明，通过设计的平台过滤ackr的生物活性可以通过多靶点预防t2dm衍生的并发症。

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A signpost to guide the key therapeutic components of Aralia continentalis Kitag roots in treating T2DM-derived heart attack, and diabetic nephropathy via systems biology concept

Aims

Aralia continentalis Kitag roots (ACKRs) have been regarded as a nutritional natural resource for treating different diseases, including type 2 diabetes mellitus (T2DM), and its complications (heart attack; HA, diabetic nephropathy; DN). Nonetheless, an extensive investigation of T2DM-derived complications has yet to be performed.

Main methods

Accordingly, we adopted gas chromatography–mass spectrometry (GC–MS) to identify the molecules of ACKRs, followed by the use of cheminformatics (Similarity Ensemble Approach; SEA, SwissTargetPrediction; STP), bioinformatics (STRING, DisGeNET, and OMIM), and computer screening tools to investigate its corresponding targets, in T2DM diseases and its complications.

Key findings

The primary targets (PPARG, and IL6) were confirmed via a protein–protein interaction (PPI) network, suggesting that IL6- Andrographolide, PPARA-Germacrene D, PPARD- Kaurenoic acid, PPARG- Kaurenoic acid, NR1H3- 1-Naphthalenepropanol, α-ethenyldecahydro-5-(hydroxymethyl)-α,2,5,5,8a-pentamethyl-, and FABP4- Kaurenoic acid conformers on PPAR signaling pathway might exert agonistic mode.

Significance

These findings underline that ACKRs' bioactives filtered by the devised platform could prevent T2DM-derived complications through multiple-target.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.