辨别抑郁和恢复机制的进展：与压力的神经生物学和抗抑郁药的作用有关

IF 9.6 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Psychiatry Pub Date : 2025-04-22 DOI:10.1038/s41380-025-03019-8

Philip W. Gold, Ma-Li Wong

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引用次数: 0

摘要

抑郁症是一种失调的应激反应，具有显著的心理和健康影响。本文综述了抑郁和心理恢复的神经生物学机制，重点探讨了压力介质如何影响对严重压力源的易感性而不是心理恢复。我们分析了大脑关键区域的结构和功能改变、遗传因素和潜在的治疗干预措施。了解这些机制有助于预防抑郁症的发作，而不仅仅是治疗其表现形式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advances in discerning the mechanisms underlying depression and resiliency: relation to the neurobiology of stress and the effects of antidepressants

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Advances in discerning the mechanisms underlying depression and resiliency: relation to the neurobiology of stress and the effects of antidepressants

Depression denotes a dysregulated stress response with significant mental and health implications. This review examines the neurobiological mechanisms underlying depression and resilience, focusing on how stress mediators influence vulnerability to severe stressors contrasted with resilience. We analyze structural and functional alterations in key brain regions, genetic factors, and potential therapeutic interventions. Understanding these mechanisms offers insights into preventing depression onset instead of solely treating its manifestations.

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来源期刊

Molecular Psychiatry 医学-精神病学

CiteScore

20.50

自引率

4.50%

发文量

459

审稿时长

4-8 weeks

期刊介绍： Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.