肿瘤免疫学：一个短的IL18裂解产物促进肿瘤免疫监测

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-04-23 DOI:10.1038/s41392-025-02213-y

Emma Guilbaud, Lorenzo Galluzzi

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引用次数: 0

摘要

在最近发表于《Nature Immunology》的一项研究中，Shen等人提出，暴露于凋亡诱导剂的恶性细胞中，caspase 3 （CASP3）依赖性的白细胞介素18 （il - 18）的切割会产生一个短的il - 18片段，该片段在细胞内作用，促进ifn刺激基因15 （ISG15）泛素样修饰物的分泌，最终将自然杀伤细胞（NK）募集到肿瘤微环境中，以支持癌症免疫监测虽然这些发现描述了一种新的信号通路，将恶性细胞对il - 18的非典型蛋白水解加工与抗癌免疫联系起来，但CASP3在这种信号转导级联中的实际意义尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance

查看原文本刊更多论文

Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance

In a recent study published in Nature Immunology, Shen et al. have proposed that the caspase 3 (CASP3)-dependent cleavage of interleukin 18 (IL18) in malignant cells exposed to apoptotic inducers generates a short IL18 fragment that operates intracellularly to promote the secretion of IFN-stimulated gene 15 (ISG15) ubiquitin-like modifier, culminating with the recruitment of natural killer (NK) cells to the tumor microenvironment in support of cancer immunosurveillance.¹ While these findings delineate a novel signaling pathway linking atypical proteolytic processing of IL18 by malignant cells to anticancer immunity, the actual implication of CASP3 in such a signal transduction cascade remains unclear.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.