2012-2019年美国加州种族/族裔间子宫切除术后子宫内膜癌发病趋势差异的组织学亚型分析

IF 4.5 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Jingjing Xie , Frances B. Maguire , Brenda M. Hofer , Julianne J.P. Cooley , Hui A. Chen , Arti Parikh-Patel , Theresa H.M. Keegan
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引用次数: 0

摘要

背景:在少数种族/民族人群中,子宫切除术后子宫内膜癌发病率的组织学亚型和年龄组的研究尚未得到很好的研究。研究加州妇女子宫切除术后子宫内膜癌发病率的最新趋势,包括组织学亚型、种族/民族和年龄组。方法通过行为危险因素监测系统估计子宫切除术的患病率。使用加州癌症登记处的数据计算了2012年至2019年子宫切除术后按子宫内膜样和非子宫内膜样亚型、诊断年龄、种族和民族划分的年龄标准化子宫内膜癌发病率(每10万名妇女)。估计发病率和年百分比变化(APC)。结果在子宫内膜样亚型中,美洲印第安妇女的发病率最高(62.9 / 10万)。亚洲/太平洋岛民的发病率也显著增加(1.69%),其中45-54岁和55-64岁女性的发病率分别增加7.14%和7.39%,但没有达到统计学意义。此外,从2012年到2019年,西班牙裔美国人的发病率增加(3.02%),2016年至2019年,25-34岁的西班牙裔美国人的发病率急剧上升(18.42%)。对于非子宫内膜样亚型,非西班牙裔黑人的发病率最高(29.4 / 10万),≥65岁年龄组呈上升趋势(2012 - 2016年增长9.39%),2017 - 2019年显著下降8.16%。美洲印第安人的发病率第二高(14.1 / 10万),但没有观察到明显的趋势,可能是由于该人群的样本量小。结论种族/民族与子宫内膜癌发病率相关,强调了将种族/民族差异与年龄和组织学亚型联合研究的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Disparities in hysterectomy-corrected endometrial cancer incidence trends by histologic subtype among racial/ethnic groups in California, 2012–2019

Background

Hysterectomy-corrected endometrial cancer incidence among racial/ethnic minority groups by histologic subtype and age group has not been well studied. To examine recent trends in hysterectomy-corrected endometrial cancer rates among California women by histologic subtype, race/ethnicity, and age group.

Methods

We estimated hysterectomy prevalence from the Behavioral Risk Factor Surveillance System. Hysterectomy-corrected age-standardized endometrial cancer incidence rates (per 100,000 women) by endometrioid and non-endometrioid subtypes, age at diagnosis, and race and ethnicity from 2012 to 2019 were calculated using California Cancer Registry data. Incidence rates and annual percentage changes (APC) were estimated.

Results

Among endometrioid subtypes, American Indian women had the highest incidence (62.9 per 100,000). Incidence rates also significantly increased among Asians/Pacific Islanders (1.69 %), with an increase of 7.14 % and 7.39 % for women aged 45–54 and 55–64, respectively, though these did not reach statistical significance. In addition, Hispanics had an increased incidence rate (3.02 %) from 2012 to 2019, with a particularly sharp rise (18.42 %) observed in Hispanics aged 25–34 years between 2016 and 2019. For non-endometrioid subtypes, non-Hispanic Blacks had the highest incidence (29.4 per 100,000), with the ≥65 age group showing an upward trend (9.39 % increase from 2012 to 2016) before significantly declining by 8.16 % from 2017 to 2019. American Indians had the second-highest incidence (14.1 per 100,000), but no significant trend was observed, likely due to the small sample size of this population.

Conclusions

Our findings show that race/ethnicity is associated with endometrial cancer incidence and underscore the importance of jointly examining racial/ethnic disparities with age and histologic subtype.
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来源期刊
Gynecologic oncology
Gynecologic oncology 医学-妇产科学
CiteScore
8.60
自引率
6.40%
发文量
1062
审稿时长
37 days
期刊介绍: Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy
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