疲劳在肌炎中很常见，并与疾病活动性有关

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-04-18 DOI:10.1016/j.semarthrit.2025.152730

Tissa Bijoy George , Shiri Keret , Anjana Chandrasekhara Pillai , Siamak Moghadam-Kia , Chester V. Oddis , Ren Dianxu , Rohit Aggarwal

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引用次数: 0

摘要

背景：疲劳是特发性炎症性肌病（IIM）患者经常报告的一种普遍的衰弱症状。本研究探讨肌炎患者疲劳的信度、效度、反应性及其与疾病活动度的相关性。方法成人IIM患者入组一项前瞻性观察研究。在基线、3个月和6个月收集肌炎核心组测量值和功能测量值，同时每月评估患者导向的结果。使用短表(SF)-36的能量-疲劳平均分量和10厘米视觉模拟量表（VAS）来评估疲劳。结果入选50例患者（女性60%，白种人94%），平均年龄51.6±14.9岁。大多数患者报告中度至重度疲劳（67%基于疲劳VAS， 52%通过能量疲劳平均）。两种疲劳测量都显示出较强的重测可靠性。在疲劳和各种肌炎结果测量（包括肌肉和肌肉外疾病、医生总体评估、疼痛、身体功能和生活质量测量）之间，显示了中度至强烈的基线相关性以及纵向相关性。根据2016年ACR/EULAR反应标准以及医生和患者报告的疾病活动变化评估，疲劳随着肌炎疾病活动的改善而显著改善。结论疲劳是肌炎患者常见的心理特征，具有良好的信度、效度和反应性。疲劳的改善与疾病活动的改善相结合，在临床试验和实践中都应被视为疾病活动的一个组成部分。

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Fatigue is common in myositis and is associated with disease activity

Background

Fatigue is a prevalent and debilitating symptom frequently reported by patients with idiopathic inflammatory myopathies (IIM). This study investigated the reliability, validity and responsiveness of fatigue in myositis, along with its correlation with disease activity.

Methods

Adults with IIM were enrolled in a prospective observational study. Myositis core set measures and functional measures were collected at baseline, 3 months and 6 months, while patient-oriented outcomes were assessed monthly. Fatigue was evaluated using the energy-fatigue average component of the Short Form (SF)-36, and a 10 cm Visual Analog Scale (VAS).

Results

Fifty patients (60 % females, 94 % Caucasian) with a mean age of 51.6 ± 14.9 years were enrolled. The majority of patients reported moderate to severe fatigue (67 % based on fatigue VAS and 52 % through the energy-fatigue average). Both fatigue measures showed strong test-retest reliability. Moderate to strong baseline association, along with a longitudinal correlation, was demonstrated between fatigue and various myositis outcome measures, encompassing both muscle and extra muscular disease, physician global assessment, pain, physical function, and quality of life measures. Fatigue significantly improved with improvement in myositis disease activity as assessed by 2016 ACR/EULAR response criteria as well as physician and patient-reported assessments of change in disease activity.

Conclusion

Fatigue is common in myositis, and demonstrates favorable psychometric properties including reliability, validity and responsiveness. Fatigue improves in conjunction with improvement in disease activity and should be regarded as an integral component of disease activity in both clinical trials and practice.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.