探索肾细胞癌转移前生态位的分子和细胞机制

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-04-22 DOI:10.1186/s12943-025-02315-9

Xiao Zhou, Ruirui Li, Maode Lai, Chong Lai

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引用次数: 0

摘要

肾细胞癌（RCC）是最常见的癌症类型之一，其转移是其死亡率升高的主要原因。在原发肿瘤转移到继发或远处器官之前，它重塑了这些部位的微环境，创造了一个有利于转移性肿瘤定植和生长的转移前生态位（PMN）。RCC释放多种生物分子，诱导血管生成，改变血管通透性，调节免疫细胞形成免疫抑制微环境，影响细胞外基质重塑和代谢重编程，并通过不同的信号通路决定转移的器官亲和性。本文综述了肾细胞癌转移前生态位形成的主要过程和机制。此外，我们强调靶向PMNs在未来治疗方法中预防和治疗肿瘤转移的重要性和潜力。最后，我们总结了目前RCC中PMN检测和治疗的潜在靶向策略，并为进一步深入研究RCC中PMN提供了路线图。

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Exploring molecular and cellular mechanisms of Pre-Metastatic niche in renal cell carcinoma

Renal cell carcinoma (RCC) is among the most frequently occurring types of cancer, and its metastasis is a major contributor to its elevated mortality. Before the primary tumor metastasizes to secondary or distant organs, it remodels the microenvironment of these sites, creating a pre-metastatic niche (PMN) conducive to the colonization and growth of metastatic tumors. RCC releases a variety of biomolecules that induce angiogenesis, alter vascular permeability, modulate immune cells to create an immunosuppressive microenvironment, affect extracellular matrix remodeling and metabolic reprogramming, and determine the organotropism of metastasis through different signaling pathways. This review summarizes the principal processes and mechanisms underlying the formation of the premetastatic niche in RCC. Additionally, we emphasize the significance and potential of targeting PMNs for the prevention and treatment of tumor metastasis in future therapeutic approaches. Finally, we summarized the currently potential targeted strategies for detecting and treating PMN in RCC and provide a roadmap for further in-depth studies on PMN in RCC.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

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