{"title":"生态友好型高效薄层色谱法定量原料药和制剂中的曲酸","authors":"Esha Jain, Amruta Balekundri","doi":"10.1007/s40009-024-01453-w","DOIUrl":null,"url":null,"abstract":"<div><p>This study presents an innovative High-Performance Thin-Layer Chromatography (HPTLC) method for quantifying Kojic Acid (KA) in bulk and formulated products. Derived from various fungi, KA is widely used across industries, driving the need for efficient, eco-friendly analysis. The method, validated according to ICH guidelines, uses pre-coated silica gel 60F254 plates and a specific mobile phase, demonstrating excellent linearity (Y = 0.008x - 0.005, R² = 0.995) and high sensitivity (LOD: 0.48 μg/band, LOQ: 1.46 μg/band). It accurately quantifies KA in gel formulations with a concentration of 0.051 ± 0.056 μg/mL. Achieving a high greenness score of 0.81 on the Analytical GREEnness (AGREE) scale, this method is cost-effective, precise, and environmentally sustainable, ideal for routine industrial applications.</p></div>","PeriodicalId":717,"journal":{"name":"National Academy Science Letters","volume":"48 2","pages":"191 - 194"},"PeriodicalIF":1.2000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eco-friendly High Performance Thin Layer Chromatography Technique for Quantification of Kojic Acid in Bulk and Formulations\",\"authors\":\"Esha Jain, Amruta Balekundri\",\"doi\":\"10.1007/s40009-024-01453-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study presents an innovative High-Performance Thin-Layer Chromatography (HPTLC) method for quantifying Kojic Acid (KA) in bulk and formulated products. Derived from various fungi, KA is widely used across industries, driving the need for efficient, eco-friendly analysis. The method, validated according to ICH guidelines, uses pre-coated silica gel 60F254 plates and a specific mobile phase, demonstrating excellent linearity (Y = 0.008x - 0.005, R² = 0.995) and high sensitivity (LOD: 0.48 μg/band, LOQ: 1.46 μg/band). It accurately quantifies KA in gel formulations with a concentration of 0.051 ± 0.056 μg/mL. Achieving a high greenness score of 0.81 on the Analytical GREEnness (AGREE) scale, this method is cost-effective, precise, and environmentally sustainable, ideal for routine industrial applications.</p></div>\",\"PeriodicalId\":717,\"journal\":{\"name\":\"National Academy Science Letters\",\"volume\":\"48 2\",\"pages\":\"191 - 194\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2024-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"National Academy Science Letters\",\"FirstCategoryId\":\"4\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40009-024-01453-w\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"National Academy Science Letters","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1007/s40009-024-01453-w","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Eco-friendly High Performance Thin Layer Chromatography Technique for Quantification of Kojic Acid in Bulk and Formulations
This study presents an innovative High-Performance Thin-Layer Chromatography (HPTLC) method for quantifying Kojic Acid (KA) in bulk and formulated products. Derived from various fungi, KA is widely used across industries, driving the need for efficient, eco-friendly analysis. The method, validated according to ICH guidelines, uses pre-coated silica gel 60F254 plates and a specific mobile phase, demonstrating excellent linearity (Y = 0.008x - 0.005, R² = 0.995) and high sensitivity (LOD: 0.48 μg/band, LOQ: 1.46 μg/band). It accurately quantifies KA in gel formulations with a concentration of 0.051 ± 0.056 μg/mL. Achieving a high greenness score of 0.81 on the Analytical GREEnness (AGREE) scale, this method is cost-effective, precise, and environmentally sustainable, ideal for routine industrial applications.
期刊介绍：
The National Academy Science Letters is published by the National Academy of Sciences, India, since 1978. The publication of this unique journal was started with a view to give quick and wide publicity to the innovations in all fields of science
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