HSP40 蛋白在基因组维护、胰岛素信号传导和癌症治疗中的作用

IF 2.7 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2025-04-17 DOI:10.1016/j.dnarep.2025.103839

Yaping Huang , Guo-Min Li

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引用次数: 0

摘要

DnaJ热休克蛋白家族（HSP40）是哺乳动物细胞中最大的伴侣蛋白家族，主要作为HSP70的伴侣蛋白，在正常和应激条件下维持蛋白稳态和细胞稳态。尽管hsp70在包括基因组维持在内的多种生物学途径和衰老过程中的功能已被广泛研究，但hsp40在基础状态或外源性损伤反应中的生物学功能仍未得到充分研究。新出现的证据表明，HSP40蛋白参与基因组维持途径并调节癌症治疗效果。本文综述了近年来HSP40在基因组维持和肿瘤治疗中的作用，并对该领域的进一步研究提供了提示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy

The DnaJ heat shock protein family (HSP40) is the biggest chaperone family in mammalian cells, mainly functioning as cochaperone of HSP70 to maintain proteostasis and cellular homeostasis under both normal and stressful conditions. Although the functions of HSP70s have been extensively studied in diverse biological pathways and senesces including genome maintenance, HSP40s’ biological functions at basal state or in response to exogenous insults remain largely under-investigated. Emerging evidence shows that HSP40 proteins participate in genome maintenance pathways and modulate cancer therapy efficacy. This review aims to summarize recent progresses regarding HSP40’s functions in genome maintenance and cancer therapy, and provides hints for future studies in the field.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.