用于在 CT 引导下进行肺癌介入治疗时准确预测呼吸运动的新型群体特征加权稀疏模型

IF 5.4 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Guo-Ren Xia , Tengfei Wang , Jun Xu , Xiaoyang Li , Hongzhi Wang , Stephen T.C. Wong , Hai Li
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引用次数: 0

摘要

准确跟踪肺结节运动是图像引导干预的关键挑战。目前的方法通常依赖于呼吸运动建模来优化诊断和治疗。基于人群的运动模型通过从群体水平的成像数据中提取肺运动的共同特征来实时预测肺运动,但它们通常忽略了个体差异。相反,针对特定患者的模型需要针对特定患者的四维计算机断层扫描(4D CT),这会增加辐射损伤。本文提出了一种新的种群特征加权稀疏(PCWS)模型。PCWS将人群水平的运动特征与患者特定数据相结合,以准确预测肺部运动,从而消除了对4D CT采集的需要。稀疏流形聚类是用来确定一个亚群显示运动模式类似的目标患者。然后使用来自该亚群的运动数据的稀疏线性组合来近似特定患者的呼吸运动场。实验结果表明,PCWS模型的平均肺估计误差为0.20 ± 0.15 mm,验证了其准确性。同时,PCWS模型在预测精度上优于其他三种先进模型,有效地结合了群体模型和患者特异性模型的优势。为了评估PCWS模型的可重复性,使用了来自不同临床中心的另外两个数据集。结果证实了该方法在各种评价标准下的准确性和重复性,进一步验证了其优越的性能。未来的研究重点是将PCWS模型应用于图像引导下的经皮肺活检和放射治疗,以提高手术精度和临床效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel population-characteristic weighted sparse model for accurate respiratory motion prediction in CT-guided lung cancer interventions
Accurate tracking of lung nodule movement is a critical challenge for image-guided interventions. Current approaches typically rely on respiratory motion modeling to optimize diagnosis and treatment. Population-based motion models predict lung movement in real time by extracting common features of lung motion from the group-level imaging data, but they usually overlook individual differences. Conversely, patient-specific models require patient-specific four-dimensional computed tomography (4D CT), which increases radiation damage. This study introduces a novel Population-Characteristic Weighted Sparse (PCWS) model. PCWS combines population-level motion characteristics with patient-specific data to accurately predict lung movement, eliminating the need for 4D CT acquisition. Sparse manifold clustering is employed to identify a subpopulation exhibiting motion patterns similar to those of the target patient. The respiratory motion field for the specific patient is then approximated using a sparse linear combination of motion data from this subpopulation. Experimental results demonstrate that the PCWS model achieves an average lung estimation error of 0.20 ± 0.15 mm, validating its accuracy. Meanwhile, the PCWS model outperforms three other advanced models in prediction accuracy, effectively combining the strengths of both population and patient-specific models. To evaluate the reproducibility of the PCWS model, two additional datasets from different clinical centers were used. The results confirmed its accuracy and repeatability across various evaluation criteria, further validating its superior performance. Future research will focus on applying the PCWS model to image-guided percutaneous lung biopsy and radiation therapy, aiming to enhance procedural precision and clinical outcomes.
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来源期刊
CiteScore
10.70
自引率
3.50%
发文量
71
审稿时长
26 days
期刊介绍: The purpose of the journal Computerized Medical Imaging and Graphics is to act as a source for the exchange of research results concerning algorithmic advances, development, and application of digital imaging in disease detection, diagnosis, intervention, prevention, precision medicine, and population health. Included in the journal will be articles on novel computerized imaging or visualization techniques, including artificial intelligence and machine learning, augmented reality for surgical planning and guidance, big biomedical data visualization, computer-aided diagnosis, computerized-robotic surgery, image-guided therapy, imaging scanning and reconstruction, mobile and tele-imaging, radiomics, and imaging integration and modeling with other information relevant to digital health. The types of biomedical imaging include: magnetic resonance, computed tomography, ultrasound, nuclear medicine, X-ray, microwave, optical and multi-photon microscopy, video and sensory imaging, and the convergence of biomedical images with other non-imaging datasets.
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