合成归巢内切酶基因驱动彻底改变埃及伊蚊的生物防治——游戏规则改变者还是白日梦？

IF 5.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2025-04-08 DOI:10.1016/j.cois.2025.101373

Joshua XD Ang , Sebald AN Verkuijl , Michelle AE Anderson , Luke Alphey

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引用次数: 0

摘要

埃及伊蚊传播的疾病，特别是登革热的负担日益加重，是一个日益引起全球关注的问题，气候变化进一步加剧了这一问题。目前的控制策略已被证明是不够的，需要新的方法。合成归巢内切酶基因（sHEG）驱动是为数不多的新兴技术之一，有可能为这一不断升级的公共卫生挑战提供具有成本效益和公平的解决方案。然而，尽管多次尝试，Ae的归巢效率。埃及伊蚊的sHEG系统落后于按蚊的sHEG系统。我们讨论了在美国发展sheg的关键见解。并强调可能开启该物种进一步发展的关键因素。

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Synthetic homing endonuclease gene drives to revolutionise Aedes aegypti biocontrol — game changer or pipe dream?

The increasing burden of Aedes aegypti–borne diseases, particularly dengue, is a growing global concern, further exacerbated by climate change. Current control strategies have proven insufficient, necessitating novel approaches. Synthetic homing endonuclease gene (sHEG) drives represent one of the few emerging technologies with the potential to offer a cost-effective and equitable solution to this escalating public health challenge. However, despite multiple attempts, the homing efficiencies of Ae. aegypti sHEG systems lag behind those achieved in Anopheles mosquitoes. We discuss key insights from efforts to develop sHEGs in Ae. aegypti and highlight critical factors that may unlock further advances in this species.

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.