IL-27：超频细胞毒性T淋巴细胞促进癌症免疫治疗

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-04-21 DOI:10.1038/s41392-025-02212-z

Silvia Dusi, Vincenzo Bronte, Francesco De Sanctis

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引用次数: 0

摘要

在最近发表在《自然》杂志上的一项研究中，Breart等人1解开了围绕白介素(IL)-27在癌症中调节T细胞分化和免疫反应中的作用的争议。他们的研究结果表明，IL-27增强肿瘤浸润性CD8+ T淋巴细胞（TILs）的持久性和效应功能，防止衰竭，维持T细胞依赖性肿瘤控制和免疫治疗效果，而无明显的全身副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy

查看原文本刊更多论文

IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy

In a recent study published in Nature, Breart et al.¹ untangled the controversy surrounding interleukin (IL)-27’s role in regulating T cell differentiation and immune responses in cancer. Their findings reveal that IL-27 enhances the persistence and effector functions of tumor-infiltrating CD8⁺ T lymphocytes (TILs), preventing exhaustion, sustaining T cell-dependent tumor control and immunotherapy efficacy without significant systemic side effects.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.