帕米膦酸钠诱导的慢性非细菌性骨髓炎临床缓解与Vγ9Vδ2 t细胞受体表达降低相关

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-04-21 DOI:10.1002/eji.202451609

Lily Watson, Athimalaipet V Ramanan, Elizabeth Oliver, Francisca Segers, Gareth W. Jones, Christine Chew, Anu Goenka

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引用次数: 0

摘要

慢性非细菌性骨髓炎患儿，经帕米膦酸钠治疗后，检测外周血的临床和转录变化。临床有效的帕米膦酸钠治疗与编码Vγ9Vδ2 t细胞受体亚基的两个基因（TRDV2和TRGV9）的表达降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pamidronate-Induced Clinical Remission in Chronic Non-bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T-Cell Receptor Expression

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Pamidronate-Induced Clinical Remission in Chronic Non-bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T-Cell Receptor Expression

In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.