粗糙型脓肿分枝杆菌通过ROS/p65/NLRP3/ gsdmd介导的巨噬细胞热亡增强毒力

IF 2.9 4区 医学 Q2 Medicine
Jingren Li, Juan Li, Anqi Li, Zhili Tan, Junsheng Fan, Siyuan He, Qi Guo, Liyun Xu, Haiqing Chu
{"title":"粗糙型脓肿分枝杆菌通过ROS/p65/NLRP3/ gsdmd介导的巨噬细胞热亡增强毒力","authors":"Jingren Li,&nbsp;Juan Li,&nbsp;Anqi Li,&nbsp;Zhili Tan,&nbsp;Junsheng Fan,&nbsp;Siyuan He,&nbsp;Qi Guo,&nbsp;Liyun Xu,&nbsp;Haiqing Chu","doi":"10.1111/1440-1681.70034","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The rough morphotype of <i>Mycobacterium abscessus</i> exhibits significantly higher virulence compared to the smooth morphotype, yet the underlying molecular mechanisms remain incompletely understood. Pyroptosis in macrophages plays a pivotal role in lung tissue damage; however, its specific involvement in <i>Mycobacterium abscessus</i> infection remains to be fully clarified. In this study, we identified that the rough morphotype of <i>Mycobacterium abscessus</i> upregulates the ROS/p65/NLRP3/GSDMD signalling pathway, thereby mediating pyroptosis in THP-1-derived macrophages. This heightened ability to induce macrophage pyroptosis is attributed to the bacterium's capacity to sustain intracellular viability and proliferation. These findings offer valuable insights into the virulence mechanisms of <i>Mycobacterium abscessus</i> and provide a foundation for future therapeutic interventions.</p>\n </div>","PeriodicalId":50684,"journal":{"name":"Clinical and Experimental Pharmacology and Physiology","volume":"52 6","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Rough Morphotype of Mycobacterium abscessus Enhances Its Virulence Through ROS/p65/NLRP3/GSDMD-Mediated Macrophage Pyroptosis\",\"authors\":\"Jingren Li,&nbsp;Juan Li,&nbsp;Anqi Li,&nbsp;Zhili Tan,&nbsp;Junsheng Fan,&nbsp;Siyuan He,&nbsp;Qi Guo,&nbsp;Liyun Xu,&nbsp;Haiqing Chu\",\"doi\":\"10.1111/1440-1681.70034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>The rough morphotype of <i>Mycobacterium abscessus</i> exhibits significantly higher virulence compared to the smooth morphotype, yet the underlying molecular mechanisms remain incompletely understood. Pyroptosis in macrophages plays a pivotal role in lung tissue damage; however, its specific involvement in <i>Mycobacterium abscessus</i> infection remains to be fully clarified. In this study, we identified that the rough morphotype of <i>Mycobacterium abscessus</i> upregulates the ROS/p65/NLRP3/GSDMD signalling pathway, thereby mediating pyroptosis in THP-1-derived macrophages. This heightened ability to induce macrophage pyroptosis is attributed to the bacterium's capacity to sustain intracellular viability and proliferation. These findings offer valuable insights into the virulence mechanisms of <i>Mycobacterium abscessus</i> and provide a foundation for future therapeutic interventions.</p>\\n </div>\",\"PeriodicalId\":50684,\"journal\":{\"name\":\"Clinical and Experimental Pharmacology and Physiology\",\"volume\":\"52 6\",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Pharmacology and Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.70034\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Pharmacology and Physiology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1440-1681.70034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

与光滑型相比,粗糙型脓肿分枝杆菌表现出明显更高的毒力,但其潜在的分子机制仍不完全清楚。巨噬细胞的焦亡在肺组织损伤中起关键作用;然而,其具体参与脓肿分枝杆菌感染仍有待充分澄清。在本研究中,我们发现脓肿分枝杆菌的粗略形态上调ROS/p65/NLRP3/GSDMD信号通路,从而介导thp -1来源的巨噬细胞的焦亡。这种诱导巨噬细胞热亡的增强能力归因于细菌维持细胞内活力和增殖的能力。这些发现为脓肿分枝杆菌的毒力机制提供了有价值的见解,并为未来的治疗干预提供了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Rough Morphotype of Mycobacterium abscessus Enhances Its Virulence Through ROS/p65/NLRP3/GSDMD-Mediated Macrophage Pyroptosis

The rough morphotype of Mycobacterium abscessus exhibits significantly higher virulence compared to the smooth morphotype, yet the underlying molecular mechanisms remain incompletely understood. Pyroptosis in macrophages plays a pivotal role in lung tissue damage; however, its specific involvement in Mycobacterium abscessus infection remains to be fully clarified. In this study, we identified that the rough morphotype of Mycobacterium abscessus upregulates the ROS/p65/NLRP3/GSDMD signalling pathway, thereby mediating pyroptosis in THP-1-derived macrophages. This heightened ability to induce macrophage pyroptosis is attributed to the bacterium's capacity to sustain intracellular viability and proliferation. These findings offer valuable insights into the virulence mechanisms of Mycobacterium abscessus and provide a foundation for future therapeutic interventions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
6.20
自引率
0.00%
发文量
128
审稿时长
6 months
期刊介绍: Clinical and Experimental Pharmacology and Physiology is an international journal founded in 1974 by Mike Rand, Austin Doyle, John Coghlan and Paul Korner. Our focus is new frontiers in physiology and pharmacology, emphasizing the translation of basic research to clinical practice. We publish original articles, invited reviews and our exciting, cutting-edge Frontiers-in-Research series’.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信