产前共暴露于邻苯二甲酸酯代谢物和双酚与神经管缺陷的关系

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Sainan Li, Haiyan Zhu, Yongyan Chen, Qianhui Cheng, Chen Yang, Jufen Liu, Lei Jin, Zhiwen Li, Aiguo Ren, Linlin Wang
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引用次数: 0

摘要

神经管缺陷是最常见的出生缺陷之一。邻苯二甲酸酯和双酚是无处不在的内分泌干扰化学物质(EDCs),它们可以通过改变激素水平来扰乱内分泌系统。然而,目前还没有关于邻苯二甲酸酯代谢物和双酚类物质共同暴露与胎儿ntd风险之间关系的研究。方法于2005 - 2016年对286名患者进行病例对照研究。采用液相色谱-串联质谱法检测胎盘中25种EDCs的含量。采用Logistic回归和多污染物模型,以母亲年龄、收集胎盘时的妊娠周数、孕前体重指数、出生缺陷史、孕期叶酸补充剂和吸烟状况为协变量,评估EDCs对新生儿NTD风险的单一和共同暴露效应。本研究还评估了怀孕小鼠在妊娠期暴露于邻苯二甲酸单-(2-乙基己基)酯(MEHP)是否会诱发后代的NTDs。结果个体暴露于高水平MEHP、邻苯二甲酸单辛酯和邻苯二甲酸单环己酯与NTD风险增加相关[优势比(OR) = 2.89, 95%可信区间(CI): 1.13, 7.43;Or = 3.00, 95% ci: 1.15, 7.85;Or = 2.78, 95% ci: 1.08, 7.18]。多污染物模型显示EDCs混合水平与NTD风险呈正相关,其中MEHP和双酚Z是主要贡献者。动物实验中,NTD率随MEHP剂量的增加而增加,趋势有统计学意义。结论本研究首次评估了孕期邻苯二甲酸酯代谢物对NTD风险的单一和共同暴露影响。我们的研究结果表明,怀孕期间暴露于邻苯二甲酸酯代谢物和双酚类物质可能会增加NTDs的风险,应加强有关环境中邻苯二甲酸酯和双酚类物质暴露的政策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of prenatal co-exposure to phthalate metabolites and bisphenols with neural tube defects

Introduction

Neural tube defects (NTDs) are one of the most common birth defects. Phthalates and bisphenols are ubiquitous endocrine-disrupting chemicals (EDCs), which can disrupt the endocrine system by altering hormone levels. However, there is no study on the associations between co-exposure to phthalate metabolites and bisphenols and risk of fetal NTDs.

Methods

A case–control study was conducted among 286 participants in China from 2005 to 2016. Liquid chromatography–tandem mass spectrometry was used to detect the levels of 25 EDCs in placenta. Logistic regression and multipollutant models were used to evaluate the single and co-exposure effects of EDCs on NTD risk, with maternal age, gestational weeks at placenta collection, pre-pregnancy body mass index, history of birth defects, folate supplementation during pregnancy, and smoking status as covariates. This study also assessed whether gestational exposure to mono-(2-ethylhexyl) phthalate (MEHP) in pregnant mice induces NTDs in offspring.

Results

Individual exposure to high levels of MEHP, mono-octyl phthalate, and mono-cyclohexyl phthalate was associated with increased NTD risk [odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.13, 7.43; OR = 3.00, 95% CI: 1.15, 7.85; OR = 2.78, 95% CI: 1.08, 7.18]. Multipollutant models showed a positive correlation between the EDCs mixture levels and NTD risk, with MEHP and bisphenol Z as the main contributors. In animal experiments, NTD rates increased with MEHP dosage, showing a statistically significant trend.

Conclusion

This is the first study to evaluate the single and co-exposure effects of phthalate metabolites during pregnancy on NTD risk. Our findings suggest that exposure to phthalate metabolites and bisphenols during pregnancy may increase the risk of NTDs, and policies regarding phthalates and bisphenols exposure in the environment should be strengthened.

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来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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