冠状动脉疾病中“易感”的定义:易感因素和预防措施

IF 2.3 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Eleni Adamopoulou, Kyriakos Dimitriadis, Konstantinos Kyriakoulis, Nikolaos Pyrpyris, Eirini Beneki, Christos Fragkoulis, Dimitris Konstantinidis, Konstantinos Aznaouridis, Konstantinos Tsioufis
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引用次数: 0

摘要

斑块引起急性冠脉综合征(ACS)的可能性取决于几个因素,既与病变有关,也与患者有关。研究最多和确定的因素之一是高风险或“易损斑块”特征的存在,这与主要不良心血管事件(MACE)的发生率增加有关。然而,认识到相当大比例的易损斑块不会导致临床事件,这使科学界倾向于“易损患者”这一更多方面的概念。将动脉粥样硬化斑块的形态特征与其血流动力学环境相结合可以更好地预测其破坏的机会,因为改变的流体动力学在斑块不稳定中起着重要作用。冠状动脉成像和计算流体动力学(CFD)领域的进步有助于开发更准确的病变和患者相关的ACS预测模型,该模型考虑了斑块的形态和施加在其上的力。这篇综述的目的是提供有关上述预测因素的最新数据以及相关的预防措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Defining “Vulnerable” in coronary artery disease: predisposing factors and preventive measures
The likelihood of a plaque to cause an acute coronary syndrome (ACS) depends on several factors, both lesion- and patient-related. One of the most investigated and established contributing factors is the presence of high-risk or “vulnerable plaque” characteristics, which have been correlated with increased incidence of major adverse cardiovascular events (MACE). The recognition, however, that a significant percentage of vulnerable plaques do not result in causing clinical events has led the scientific community towards the more multifaceted concept of “vulnerable patients”. Incorporating the morphological features of an atherosclerotic plaque into its hemodynamic surroundings can better predict the chance of its disruption, as altered fluid dynamics play a significant role in plaque destabilization. The advances in coronary imaging and the field of computational fluid dynamics (CFD) can contribute to develop more accurate lesion- and patient-related ACS prediction models that take into account both the morphology of a plaque and the forces applied upon it. The aim of this review is to provide the latest data regarding the aforementioned predictive factors as well as relevant preventive measures.
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来源期刊
Cardiovascular Pathology
Cardiovascular Pathology 医学-病理学
CiteScore
7.50
自引率
2.70%
发文量
71
审稿时长
18 days
期刊介绍: Cardiovascular Pathology is a bimonthly journal that presents articles on topics covering the entire spectrum of cardiovascular disease. The Journal''s primary objective is to publish papers on disease-oriented morphology and pathogenesis from clinicians and scientists in the cardiovascular field. Subjects covered include cardiovascular biology, prosthetic devices, molecular biology and experimental models of cardiovascular disease.
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