小麻烦:微塑料,纳米塑料,以及它们对心血管健康的衷心影响

IF 10.2 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Tongyao Zhang, Yajie Liao, Jitao Ling, Jing Zhang, Deju Zhang, Xiaoping Yin, Peng Yu, Xiao Liu
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引用次数: 0

摘要

微塑料和纳米塑料是无处不在的环境污染物,对健康构成重大威胁。一些研究报告称,这些微粒存在于各种人体组织中,包括心脏、动脉斑块和接受经皮冠状动脉介入治疗的患者的血液中。新的研究表明,这些微粒与心血管疾病风险的增加有关。体外和体内研究表明,微塑料和纳米塑料会诱导内皮细胞中毒,破坏脂质代谢,促进氧化应激,促进泡沫细胞形成,从而加剧动脉粥样硬化。此外,它们还会激活炎症通路,损害血管屏障的完整性。这些微粒还通过改变凝血级联激活和促进血栓形成来影响凝血动力学。此外,它们还会诱导溶血,改变红细胞形态,并通过调节细胞因子分泌和炎症反应来损害免疫细胞功能,包括巨噬细胞和淋巴细胞的功能。了解这些机制对于制定有效的公共卫生战略以减轻微塑料和纳米塑料对心血管的影响至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tiny trouble: microplastics, nanoplastics, and their heartfelt impact on cardiovascular health
Microplastics and nanoplastics are ubiquitous environmental pollutants that pose significant health risks. Several studies have reported the presence of these particles in various human tissues, including the heart, arterial plaques, and bloodstream of patients undergoing percutaneous coronary interventions. Emerging research suggests an association between these particles and an increased risk of cardiovascular diseases. In vitro and in vivo studies reveal that micro- and nanoplastics induce endothelial cell toxicity, disrupt lipid metabolism, promote oxidative stress, and facilitate foam cell formation, thereby exacerbating atherosclerosis. Furthermore, they activate inflammatory pathways, compromising vascular barrier integrity. These particles also influence coagulation dynamics by altering clotting cascade activation and promoting thrombus formation. Additionally, they induce hemolysis, alter red blood cell morphology, and impair immune cell functions, including those of macrophages and lymphocytes, by modulating cytokine secretion and inflammatory responses. Understanding these mechanisms is essential for devising effective public health strategies to mitigate the cardiovascular impact of micro- and nanoplastics.
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来源期刊
Cardiovascular Research
Cardiovascular Research 医学-心血管系统
CiteScore
21.50
自引率
3.70%
发文量
547
审稿时长
1 months
期刊介绍: Cardiovascular Research Journal Overview: International journal of the European Society of Cardiology Focuses on basic and translational research in cardiology and cardiovascular biology Aims to enhance insight into cardiovascular disease mechanisms and innovation prospects Submission Criteria: Welcomes papers covering molecular, sub-cellular, cellular, organ, and organism levels Accepts clinical proof-of-concept and translational studies Manuscripts expected to provide significant contribution to cardiovascular biology and diseases
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