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IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-04-18 DOI:10.1038/s42255-025-01274-1

Theresa Ramalho, Ricardo Tostes Gazzinelli

引用次数: 0

摘要

一项新的研究揭示了一种令人惊讶的机制，即伊塔康酸抑制过氧化物酶的活性位点，从而扩大巨噬细胞中的氧化还原信号和 I 型干扰素反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Itaconate boosts type I IFN response by disrupting cytoprotection

查看原文本刊更多论文

Itaconate boosts type I IFN response by disrupting cytoprotection

A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.