钯催化/钛促进的两醇Csp3-Csp3偶联：全碳季中心的生成

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-10 DOI:10.1021/acs.orglett.5c0052710.1021/acs.orglett.5c00527

Huan Liu, Ziheng Jian, Min Zhang, Xiang Hao, Zehuai Mou, Huifei Wang* and Hongbin Zhai*,

引用次数: 0

摘要

在过渡金属催化的交叉偶联反应中，天然丰富且价格低廉的醇是吸引人且合适的Csp3偶联伙伴。在两个不同的无保护醇之间完成了钯催化/钛促进的Csp3-Csp3交叉偶联。该反应以pd催化的β-H消除为特征，使亲电性π-烯丙基- pd中间体逆转为亲核二烯醇酯，并生成全碳季元中心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-Catalyzed/Titanium-Promoted Csp3–Csp3 Coupling of Two Alcohols: Generation of an All-Carbon Quaternary Center

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Palladium-Catalyzed/Titanium-Promoted Csp3–Csp3 Coupling of Two Alcohols: Generation of an All-Carbon Quaternary Center

Naturally abundant and inexpensive alcohols represent appealing and suitable Csp³ coupling partners in transition metal-catalyzed cross-coupling reactions. A palladium-catalyzed/titanium-promoted Csp³–Csp³ cross coupling between two distinct unprotected alcohols has been accomplished. The reaction features a Pd-catalyzed β-H elimination, enabling the reversal of the electrophilic π-allyl-Pd intermediate into a nucleophilic dienolate and the generation of an all-carbon quaternary center.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.