现在你看到我了，现在你看不见了：细胞质模式识别受体检测到病毒rna的内容和方式

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-04-17 DOI:10.1016/j.molcel.2025.03.019

Raul Andino, Daniel Darling

引用次数: 0

摘要

在最近一期的《分子细胞》（Molecular Cell）杂志上，genyer等人1表明，在西尼罗病毒感染期间，逃逸的、细胞质的、抗基因组负义病毒RNA通过rig - 1激活引发抗病毒反应。黄病毒通常将- vRNA隐藏在复制室中以避免被发现，但一些- vRNA可能在病毒衣壳蛋白的帮助下泄漏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Now you see me, now you don’t: What and how viral RNAs are detected by cytoplasmic pattern-recognition receptors

In a recent issue of Molecular Cell, Genoyer et al.¹ show that during West Nile virus infection, escaped, cytoplasmic, anti-genomic negative-sense viral RNA triggers an antiviral response via RIG-I activation. Flaviviruses typically hide −vRNA in replication compartments to avoid detection, but some −vRNA leaks, possibly aided by viral capsid proteins.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.