揭示G蛋白偶联受体的质子感应机制：来自低温电子显微镜研究的见解

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-04-17 DOI:10.1016/j.molcel.2025.03.020

Chenyang Xue, Zhongmin Liu

引用次数: 0

摘要

在这一期中，Guo et al.1和Chen et al.2解决了G蛋白偶联受体（GPR） 4和GPR68的低温电镜结构，揭示了组氨酸质子化引发构象重排并决定G蛋白偶联偏置，阐明了ph感应机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unraveling the proton-sensing mechanisms of G protein-coupled receptors: Insights from cryogenic electron microscopy studies

In this issue, Guo et al.¹ and Chen et al.² resolved the cryo-EM structures of G protein-coupled receptor (GPR) 4 and GPR68, unveiling that histidine protonation initiates conformational rearrangements and dictates G protein coupling bias, illuminating pH-sensing mechanisms.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.