铜通过Cu-B （sp3）配合物的中介作用催化C-B （sp3）键的形成

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-04-15 DOI:10.1021/jacs.5c00974

Zhanqiang Ye, Chun Yin Kwok, Sze Lam Lam, Linlin Wu, Hairong Lyu

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引用次数: 0

摘要

绝大多数过渡金属（TM）催化的硼化转化依赖于TM - b （sp2）配合物。相比之下，由于缺乏合适的硼（sp3）试剂，TM-B （sp3）的化学性质及其催化硼化的潜力仍然令人惊讶地不发达。在这里，我们使用我们最近开发的sp2-sp3二硼试剂成功地实现了铜催化的丙烯硼氢化反应，以形成C-B （sp3）键。一项全面的机制研究，包括Cu-B （sp3）配合物的分离和结构表征，证实了Cu-B （sp3）中间体在催化循环中的存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-Catalyzed C–B(sp3) Bond Formation through the Intermediacy of Cu–B(sp3) Complex

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Copper-Catalyzed C–B(sp3) Bond Formation through the Intermediacy of Cu–B(sp3) Complex

The vast majority of transition metal (TM) catalyzed borylative transformations rely on TM–B(sp²) complexes. Contrastingly, the chemistry of TM–B(sp³) species and their potential in catalytic borylation remain surprisingly underdeveloped, due probably to the lack of suitable boron(sp³) reagents. Herein, we employ our recently developed sp²-sp³ diboron reagent to successfully enable a copper-catalyzed hydroboration of allenes for C–B(sp³) bond formation. A comprehensive mechanistic study, including the isolation and structural characterization of a Cu–B(sp³) complex, substantiates the presence of a Cu–B(sp³) intermediate in the catalytic cycle.

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.