无卒中心房颤动患者的甘油三酯-葡萄糖指数与认知功能之间的关系：一项横断面研究

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-04-12 DOI:10.1016/j.clineuro.2025.108890

Juncun Wu , Zhetao Wang , Chen Ye , Junfeng Liu , Shi Chen , Wendan Tao , Fabao Gao , Zilong Hao

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引用次数: 0

摘要

目的房颤（AF）患者的甘油三酯-葡萄糖（TyG）指数与认知功能之间的相关性尚未有研究证实。本研究的目的是检验这种潜在的联系。方法于2021年3月至2022年5月在四川大学华西医院心内科诊断为房颤的患者入组研究。计算TyG指数。认知功能评估采用最小精神状态检查（MMSE）量表和蒙特利尔认知评估（MoCA）、语言流畅性测试（VFT）、形状轨迹测试（STT）、数字符号替代测试（DSST）和Stroop C评分和秒数。采用Logistic回归分析检验TyG指数（连续和四分位数）与认知功能之间的关系。结果共纳入142例患者。TyG指数中位数为1.28（1.01,1.71）。在调整潜在混杂因素后，未发现TyG指数第4四分位数的参与者与认知功能相关（P均为 >； 0.05）。作为连续变量的TyG的结果与这些结果一致。结论：在房颤患者中，TyG指数与认知功能低下无关，可通过一系列综合测试进行评估。这些发现应在进一步的研究中得到验证。

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Association between the triglyceride-glucose index and cognitive function in stroke free patients with atrial fibrillation: A cross-sectional study

Objectives

No existing research has documented the correlation between the triglyceride-glucose (TyG) index and cognitive function in patients suffering from atrial fibrillation (AF). The objective of this study is to examine this potential association.

Methods

Patients diagnosed with AF were enrolled in this study from March 2021 to May 2022 at the cardiology department of West China Hospital, Sichuan University. TyG index was calculated. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE) scale and Montreal Cognitive Assessment (MoCA), Verbal Fluency Test (VFT), Shape Trail Test (STT), Digit Symbol Substitution Test (DSST), and Stroop C scores and seconds. Logistic regression analyses were conducted to examine the association between the TyG index (continuous and quartiles) and cognitive function.

Results

A total of 142 patients were included. The median value of the TyG index was 1.28 (1.01, 1.71). After adjusted potential confounding factors, participants in the 4th quartile of the TyG index were not found to be associated with cognitive function (all P > 0.05). The findings for TyG as a continuous variable were consistent with these results.

Conclusion

In patients with AF, the TyG index was found to be unrelated to low cognitive function as assessed by a comprehensive battery of tests. These findings should be validated in further studies.

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.