世界各国与类风湿性关节炎相关的间质性肺病

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-04-12 DOI:10.1016/j.semarthrit.2025.152719

Sascha L Heckert , Tjardo D Maarseveen , Emiel R Marges , Arvind Chopra , David Vega-Morales , Riette du Toit , Lai Ling Winchow , Nimmisha Govind , Carlos E Toro-Gutiérrez , Rachel Knevel , Annette HM van der Helm–van Mil , Tom WJ Huizinga , Cornelia F Allaart , Sytske Anne Bergstra

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引用次数: 0

摘要

目的：我们旨在描述RA- ild在全球不同国家的发病率，并探讨其与RA疾病活动性的关系。方法收集5个国家的两个观察数据库（METEOR， EAC）中RA- ild（基于胸部x线或CT的临床诊断）患者的数据。我们调查了疾病活动性与RA-ILD之间的可能关联。结果对16663例不同病程的RA患者进行了评估。在数据库记录的首次就诊时，荷兰1/1077（0.09%）、印度63/11,787（0.53%）、南非8/629（1.27%）、墨西哥6/424（1.42%）和哥伦比亚17/2728（0.62%）的患者诊断为RA-ILD。在新诊断的RA患者中，RA- ild的发病率在荷兰为每1000患者年3.8例（95% CI 1.6 - 9.1），印度为1.6例（95% CI 1.0 - 2.5），南非为6.6例（95% CI 2.5 - 17.5）。随着时间的推移，DAS28每增加一点，RA-ILD发展的OR为1.19 （95% CI 0.34至4.22）。RA-ILD诊断后或匹配时间点的疾病活动性在RA-ILD患者中显著高于对照组（β 0.56 (95% CI 0.18 - 0.93)）。两组间DMARD的使用无明显差异。结论尽管不同国家之间RA- ild的患病率和发病率略有差异，但在我们不同大洲的RA人群中，RA- ild的日常发病率较低。RA-ILD患者比非RA-ILD患者有更高的疾病活动性，并且更常为ACPA阳性和/或（前）吸烟者。

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Rheumatoid arthritis-associated interstitial lung disease in countries across the world

Objectives

We aimed to describe the incidence of RA-ILD in various countries worldwide, and to explore its association with RA disease activity.

Methods

In 5 countries, data on RA-ILD (clinical diagnosis based on chest X-ray or CT) were collected RA patients of two observational databases (METEOR, EAC). We investigated a possible association between disease activity over time and RA-ILD.

Results

16,663 patients with RA with variable disease duration were evaluated. At the first visit recorded in the database, 1/1077 (0.09 %) patients from The Netherlands, 63/11,787 (0.53 %) from India, 8/629 (1.27 %) from South Africa, 6/424 (1.42 %) from Mexico and 17/2728 (0.62 %) from Colombia had an RA-ILD diagnosis. The incidence rate of RA-ILD in patients with newly diagnosed RA was 3.8 (95 % CI 1.6 to 9.1) per 1000 patient years in The Netherlands, 1.6 (95 % CI 1.0 to 2.5) in India and 6.6 (95 % CI 2.5–17.5) in South Africa. The OR for RA-ILD development, per point increase in DAS28 over time was 1.19 (95 % CI 0.34 to 4.22). Disease activity after the RA-ILD diagnosis or a matched timepoint was statistically significantly higher in patients with RA-ILD than in controls (β 0.56 (95 % CI 0.18 to 0.93). There were no clear differences in DMARD use between the two groups.

Conclusion

Despite slight differences in RA-ILD prevalence and incidence between countries, the incidence of RA-ILD in daily practice is low in our RA population from different continents. Patients with RA-ILD had a higher disease activity than patients without RA-ILD, and were more often ACPA positive and/or (former) smokers.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.