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89Zr-DFO（脱氧胺）配合物中的协同配位：计算和实验对辅助配体的启示

IF 6.1 1区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR
Inorganic Chemistry Frontiers Pub Date : 2025-04-14 DOI:10.1039/d5qi00879d
Jiarui Li, Chenghe Ding, Yang Gao, Lili Wen, Pingping Zhao, Lu Zhou, Rui Luo, Mingsong Shi, Georg Schreckenbach, Xiaoan Li, Zhiming Wang
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引用次数: 0

摘要

本研究采用计算和实验相结合的方法研究了辅助配体如何增强六配位89Zr-DFO（去铁胺）配合物的热力学稳定性。与H2O、Cl-、CO32-和C2O42-相比，强静电相互作用更有利于HPO42-，这表明HPO42-在先进的医疗诊断和治疗应用中具有优越的稳定性。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Synergistic Coordination in 89Zr-DFO (Deferoxamine) Complexes: Computational and Experimental Insights into Auxiliary Ligands
This study combines computational and experimental methods to investigate how auxiliary ligands enhance thermodynamic stability in hexacoordinate 89Zr-DFO (Deferoxamine) complexes. Strong electrostatic interactions favour HPO42- over H2O, Cl-, CO32- and C2O42-, indicating superior stability for advanced medical diagnostics and treatment applications.
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来源期刊
Inorganic Chemistry Frontiers
Inorganic Chemistry Frontiers CHEMISTRY, INORGANIC & NUCLEAR-
CiteScore
10.40
自引率
7.10%
发文量
587
审稿时长
1.2 months
期刊介绍： The international, high quality journal for interdisciplinary research between inorganic chemistry and related subjects
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