脂肪组织向大脑传递的信号不仅仅是瘦素

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-04-15 DOI:10.1038/s42255-025-01277-y

Peter Arner

引用次数: 0

摘要

Nature Metabolism的一项研究表明，在急性应激下，白色脂肪细胞脂解释放的脂肪酸导致局部巨噬细胞释放生长分化因子GDF15，而GDF15反过来与大脑中的受体GFRAL结合，引起焦虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Signalling from adipose tissue to the brain is not just about leptin

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Signalling from adipose tissue to the brain is not just about leptin

A Nature Metabolism study shows that, under acute stress, fatty acids liberated by lipolysis of white fat cells cause release from local macrophages of the growth-differentiation factor GDF15, which, in turn, binds to the receptor GFRAL in the brain, evoking anxiety.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.