美国临床内分泌学协会关于多发性内分泌肿瘤 1 型管理的共识声明

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-04-01 DOI:10.1016/j.eprac.2025.02.001

Jaydira Del Rivero MD , Alexandra Gangi MD , Justin P. Annes MD, PhD , Sina Jasim MD, MPH , Jason Keller PhD , Michelle D. Lundholm MD , Julie M. Silverstein MD , Tanaz M. Vaghaiwalla MD, MS , Robert A. Wermers MD

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引用次数: 0

摘要

目的：本文介绍美国临床内分泌学会（AACE）对多发性1型内分泌瘤（MEN1）及相关肿瘤患者的诊断、管理和监测结果。该工作组包括来自内分泌学、肿瘤学、遗传学、外科和患者代表等不同领域的专家。我们进行了一项全面的文献综述，以解决与men1相关肿瘤的评估、监测和治疗相关的关键问题。方法工作组由内分泌学、外科学、内科肿瘤学、遗传学和患者倡导等领域的9名专家组成，共同制定men1相关肿瘤的评估、监测和管理指南。共识定义为≤1票反对，显著多数为≥75%。相关研究是通过文献回顾过程确定的，共识声明是基于现有证据的。结果工作组审议了men1相关肿瘤的监测、评估和管理，包括甲状旁腺、垂体、胃肠胰神经内分泌肿瘤和其他相关肿瘤。该文件还说明了MEN1基因检测的适应症。结论：本共识声明旨在为参与MEN1及相关肿瘤患者护理的卫生保健提供者提供循证指导。它提供了诊断工具、基因检测标准、成像技术、手术干预和治疗后监测方面的指导。本文概述的实用、以患者为中心的方法旨在改善MEN1和其他高危内分泌肿瘤患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American Association of Clinical Endocrinology Consensus Statement on Management of Multiple Endocrine Neoplasia Type 1

Objective

This document presents the findings of the American Association of Clinical Endocrinology (AACE) on the diagnosis, management, and surveillance of patients with multiple endocrine neoplasia type 1 (MEN1) and associated tumors. The task force included a diverse group of experts in endocrinology, oncology, genetics, surgery, and patient representation. A comprehensive literature review was conducted to address key issues related to the evaluation, surveillance, and treatment of MEN1-related tumors.

Methods

The task force, comprised of 9 members with expertise in endocrinology, surgery, medical oncology, genetics, and patient advocacy, collaborated to develop guidance for the evaluation, surveillance, and management of MEN1-associated tumors. Consensus was defined as ≤1 dissenting vote and significant majority as ≥75%. Relevant studies were identified through a literature review process, and consensus statements were based on the available evidence.

Results

The task force deliberated on the surveillance, evaluation, and management of MEN1-related tumors including parathyroid, pituitary, and gastroenteropancreatic neuroendocrine tumors and other tumors of relevance. The document also addresses the indications for MEN1 genetic testing.

Conclusions

This consensus statement aims to offer evidence-informed guidance for health care providers involved in the care of patients with MEN1 and associated tumors. It provides guidance on diagnostic tools, genetic testing criteria, imaging techniques, surgical interventions, and posttreatment monitoring. The practical, patient-centered approach outlined in this document is intended to improve outcomes for individuals with MEN1 and other high-risk endocrine tumors.

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.