Shrey Seth Pharm D, Lipin Lukose Pharm D, Wubshet H. Tesfaye BPharm, MSc, PhD, Sathvik B. Sridhar MPharm, PhD, Girish Thunga BPharm, MPharm, PhD, Ronald L. Castelino BPharm, MPharm, PhD
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However, little is known about their impact on medication regimen complexity.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>Investigate the impact of pharmacist-led HMRs on simplifying medication regimen complexity using the Medication Regimen Complexity Index (MRCI).</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>A retrospective cohort study of 196 general practitioners (GPs) initiated HMRs, conducted over a period of 2 years (2020–2022) using two credentialed pharmacists in New South Wales, Australia. MRCI was used to measure the complexity at two separate time points, at baseline and following pharmacists' recommendations (assuming the GPs accepted all of the pharmacists' recommendations provided during the HMRs). The Wilcoxon signed-rank test was used to determine the difference between the scores at baseline and after HMR. Ethical approval was granted by the University of Sydney Human Research Ethics Committee (Reference no: 2022/584) and the study conforms to the Australian <i>National statement on the ethical conduct in human research</i>.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>During the HMR service, pharmacists made a total of 792 recommendations (mean ± standard deviation [4.04 ± 2.3] per HMR), among which dosage and frequency adjustment, laboratory monitoring, and therapeutic monitoring were the most common, collectively accounting for almost half of the recommendations. The median MRCI score at baseline was 28.5 (interquartile range [IQR] 21.5–37.6) and following pharmacists' recommendations was 29 (IQR 21.9–37.1). The difference between the baseline and post-HMR scores was not statistically significant.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Our study demonstrates the lack of significant reductions in medication complexity following HMRs as measured by the MRCI. However, these results need to be interpreted with caution as not all interactions with patients lead to a change in the MRCI score. Comprehensive examination of individual medication changes may provide more meaningful and clinically relevant inferences.</p>\n </section>\n </div>","PeriodicalId":16795,"journal":{"name":"Journal of Pharmacy Practice and Research","volume":"55 2","pages":"102-109"},"PeriodicalIF":1.0000,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jppr.1945","citationCount":"0","resultStr":"{\"title\":\"Impact of Home Medicines Review on medication regimen complexity\",\"authors\":\"Shrey Seth Pharm D, Lipin Lukose Pharm D, Wubshet H. Tesfaye BPharm, MSc, PhD, Sathvik B. Sridhar MPharm, PhD, Girish Thunga BPharm, MPharm, PhD, Ronald L. Castelino BPharm, MPharm, PhD\",\"doi\":\"10.1002/jppr.1945\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Previous studies on pharmacist-led Home Medicines Review (HMR) have demonstrated positive associations of HMR and clinical outcomes. However, little is known about their impact on medication regimen complexity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>Investigate the impact of pharmacist-led HMRs on simplifying medication regimen complexity using the Medication Regimen Complexity Index (MRCI).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Method</h3>\\n \\n <p>A retrospective cohort study of 196 general practitioners (GPs) initiated HMRs, conducted over a period of 2 years (2020–2022) using two credentialed pharmacists in New South Wales, Australia. MRCI was used to measure the complexity at two separate time points, at baseline and following pharmacists' recommendations (assuming the GPs accepted all of the pharmacists' recommendations provided during the HMRs). The Wilcoxon signed-rank test was used to determine the difference between the scores at baseline and after HMR. Ethical approval was granted by the University of Sydney Human Research Ethics Committee (Reference no: 2022/584) and the study conforms to the Australian <i>National statement on the ethical conduct in human research</i>.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>During the HMR service, pharmacists made a total of 792 recommendations (mean ± standard deviation [4.04 ± 2.3] per HMR), among which dosage and frequency adjustment, laboratory monitoring, and therapeutic monitoring were the most common, collectively accounting for almost half of the recommendations. 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Impact of Home Medicines Review on medication regimen complexity
Background
Previous studies on pharmacist-led Home Medicines Review (HMR) have demonstrated positive associations of HMR and clinical outcomes. However, little is known about their impact on medication regimen complexity.
Aim
Investigate the impact of pharmacist-led HMRs on simplifying medication regimen complexity using the Medication Regimen Complexity Index (MRCI).
Method
A retrospective cohort study of 196 general practitioners (GPs) initiated HMRs, conducted over a period of 2 years (2020–2022) using two credentialed pharmacists in New South Wales, Australia. MRCI was used to measure the complexity at two separate time points, at baseline and following pharmacists' recommendations (assuming the GPs accepted all of the pharmacists' recommendations provided during the HMRs). The Wilcoxon signed-rank test was used to determine the difference between the scores at baseline and after HMR. Ethical approval was granted by the University of Sydney Human Research Ethics Committee (Reference no: 2022/584) and the study conforms to the Australian National statement on the ethical conduct in human research.
Results
During the HMR service, pharmacists made a total of 792 recommendations (mean ± standard deviation [4.04 ± 2.3] per HMR), among which dosage and frequency adjustment, laboratory monitoring, and therapeutic monitoring were the most common, collectively accounting for almost half of the recommendations. The median MRCI score at baseline was 28.5 (interquartile range [IQR] 21.5–37.6) and following pharmacists' recommendations was 29 (IQR 21.9–37.1). The difference between the baseline and post-HMR scores was not statistically significant.
Conclusion
Our study demonstrates the lack of significant reductions in medication complexity following HMRs as measured by the MRCI. However, these results need to be interpreted with caution as not all interactions with patients lead to a change in the MRCI score. Comprehensive examination of individual medication changes may provide more meaningful and clinically relevant inferences.
期刊介绍：
The purpose of this document is to describe the structure, function and operations of the Journal of Pharmacy Practice and Research, the official journal of the Society of Hospital Pharmacists of Australia (SHPA). It is owned, published by and copyrighted to SHPA. However, the Journal is to some extent unique within SHPA in that it ‘…has complete editorial freedom in terms of content and is not under the direction of the Society or its Council in such matters…’. This statement, originally based on a Role Statement for the Editor-in-Chief 1993, is also based on the definition of ‘editorial independence’ from the World Association of Medical Editors and adopted by the International Committee of Medical Journal Editors.
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