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IF 4.9 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Pub Date : 2025-04-11 DOI:10.1002/trc2.70068

Francesca R. Marino, Jennifer A. Deal, Alden L. Gross, Yang An, Qu Tian, Eleanor M. Simonsick, Luigi Ferrucci, Susan M. Resnick, Jennifer A. Schrack, Amal A. Wanigatunga

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引用次数: 0

摘要

引言体力活动是痴呆症的一个可调节风险因素，但认知功能对参与体育活动也很重要。本研究评估了认知和身体状况完好的老年人日常体育锻炼与认知功能之间关系的方向性。方法对巴尔的摩老龄化纵向研究（Baltimore Longitudinal Study of Aging，BLSA）中的 237 名认知功能完好的老年人（平均年龄：76.5 岁）进行了两次访问（平均 1.8 年），测量了包括整体认知、记忆、语言、执行功能/注意力和视觉空间处理等领域的认知因子得分，以及腕式加速度计得出的身体活动模式。双变量潜在变化得分模型估计了认知因子得分变化与体育活动模式之间的相关性。模型根据年龄、性别、种族、教育程度、合并症和体重指数进行了调整。结果在多个认知领域中，基线活动总量越高、活动时间越长、久坐时间越短、活动碎片越少与每年认知能力下降的程度越低有关（X2 > 4.11，所有数据均为 1 df）。相比之下，基线认知因子得分与任何活动模式的变化都没有关系（X2 < 3.20，所有数据均为 1 df）。讨论增加运动量和/或减少久坐行为与减少预期认知功能衰退有关。有针对性地减少久坐时间和延长活动时间可能会减缓有痴呆风险的老年人的认知能力下降。亮点更多地参与活动与较少的年度认知能力下降有关。基线认知与活动模式的短期变化无关。促进日常运动和减少久坐时间可能对认知能力有益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Directionality between cognitive function and daily physical activity patterns

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Directionality between cognitive function and daily physical activity patterns

INTRODUCTION

Physical activity is a modifiable risk factor for dementia, but cognitive function is also important for physical activity engagement. This study evaluated the directionality of associations between daily physical activity and cognitive function in a sample of cognitively and physically intact older adults.

METHODS

Cognitive factor scores for domains including global cognition, memory, language, executive function/attention, and visuospatial processing, and physical activity patterns from wrist accelerometry were measured at two visits (mean: 1.8 years) among 237 cognitively intact older adults in the Baltimore Longitudinal Study of Aging (BLSA) (mean age: 76.5 years). Bivariate latent change score models estimated directionality of associations between changes in cognitive factor scores and physical activity patterns. Models were adjusted for age, sex, race, education, comorbidities, and body mass index.

RESULTS

Higher total amount of activity, longer activity bouts, less sedentary time, and less activity fragmentation at baseline were associated with less annual cognitive decline across multiple cognitive domains (X²> 4.11, 1 df for all). In contrast, baseline cognitive factor scores were not associated with changes in any activity pattern (X² < 3.20, 1 df for all).

DISCUSSION

Increasing movement and/or decreasing sedentary behavior is associated with less prospective cognitive decline. Targeting reductions in sedentary time and lengthening activity bouts may slow cognitive decline among older adults at risk for dementia.

Highlights

Greater activity engagement is related to less annual cognitive decline.
Baseline cognition is not associated with short-term changes in activity patterns.
Promoting daily movement and lowering sedentary time may have cognitive benefits.

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来源期刊

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Medicine-Psychiatry and Mental Health

CiteScore

10.10

自引率

2.10%

发文量

134

审稿时长

10 weeks

期刊介绍： Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.