法匹拉韦和奥司他韦在微塑料存在下的臭氧化和催化臭氧化合成城市废水的降解和生态毒性

IF 2.8 4区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of chemical technology and biotechnology Pub Date : 2025-02-20 DOI:10.1002/jctb.7831

Serdar Dogruel, Nasim Chavoshi, Nilay Bilgin-Saritas, Alireza Khataee, Emel Topuz, Elif Pehlivanoglu

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引用次数: 0

摘要

Favipiravir （FAV）和oseltamivir （OSE）是针对流感开发的抗病毒药物，在COVID-19大流行期间被重新用于治疗SARS-CoV-2。本研究评估了臭氧化和催化臭氧化作为去除城市污水中FAV和OSE的三级处理方法的潜力，在存在和不存在微塑料（MPs）的情况下，同时比较了未经处理和处理的二级出水的生态毒性，以预测这些技术在城市污水处理过程中的生态毒理学效应。结果在初始抗病毒浓度为50 μg L−1的条件下，pH为7，臭氧比剂量为0.6 mg O3 (mg DOC)−1时，FAV和OSE的去除率分别为84%和64%，而催化剂或MPs的存在使降解率降低了30-40%。将pH值提高到10对减少FAV的影响最小，但使OSE减少了21%。利用费氏弧菌进行的急性毒性试验表明，分析物同时臭氧化导致FAV和OSE转化产物（TPs）的积累，其综合效果几乎等于原始化合物。生殖毒性试验表明，臭氧化过程中产生的抗病毒药物的TPs对隐泥鳅的毒性低于母体化学物质。结论臭氧氧化是对现有污水处理设施进行升级改造的一种可行选择，可作为一种补充处理，最大限度地减少城市二级废水中抗病毒药物的释放，降低其对蚯蚓繁殖的抑制作用，从而提高处理后的废水用于灌溉的回用潜力。©2025作者。化学技术与生物技术杂志，John Wiley &出版；代表化学工业学会（SCI）的儿子有限公司。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Degradation and ecotoxicity of favipiravir and oseltamivir in the presence of microplastics during ozonation and catalytic ozonation of synthetic municipal wastewater effluents

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Degradation and ecotoxicity of favipiravir and oseltamivir in the presence of microplastics during ozonation and catalytic ozonation of synthetic municipal wastewater effluents

Background

Favipiravir (FAV) and oseltamivir (OSE) are antiviral agents developed against influenza and they were repurposed against SARS-CoV-2 during the COVID-19 pandemic. This study evaluated the potential of ozonation and catalytic ozonation as tertiary treatment approaches for removing FAV and OSE from municipal wastewaters, both in the presence and absence of microplastics (MPs), while comparing the ecotoxicity of untreated and treated secondary effluents to predict the ecotoxicological effects of these technologies during municipal wastewater treatment.

Results

At an initial antiviral concentration of 50 μg L⁻¹, ozonation at pH 7 with a specific ozone dose of 0.6 mg O₃ (mg DOC)⁻¹ yielded FAV and OSE removals of 84 and 64%, respectively, while the presence of catalyst or MPs decreased the degradation rate by 30–40%. Raising the pH to 10 had minimal impact on FAV abatement, but improved OSE reduction by 21%. Acute toxicity tests using Vibrio fischeri demonstrated that simultaneous ozonation of the analytes led to the accumulation of transformation products (TPs) of FAV and OSE, with their combined effect almost equal to that of the original compounds. Reproduction toxicity tests indicated that TPs of antiviral drugs generated during ozonation were less toxic to Enchytraeus crypticus than the parent chemicals.

Conclusion

Ozonation proved to be a viable option for upgrading existing wastewater treatment facilities, serving as a complementary treatment to minimize the release of antivirals from municipal secondary effluents and reduce their inhibitory effect on earthworm reproduction, thereby enhancing the reuse potential of treated wastewater for irrigation. © 2025 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).

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来源期刊

Journal of chemical technology and biotechnology 工程技术-工程：化工

CiteScore

7.00

自引率

5.90%

发文量

268

审稿时长

1.7 months

期刊介绍： Journal of Chemical Technology and Biotechnology(JCTB) is an international, inter-disciplinary peer-reviewed journal concerned with the application of scientific discoveries and advancements in chemical and biological technology that aim towards economically and environmentally sustainable industrial processes.