运动因子介导的器官相互作用：运动对心血管功能改善的新解释

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-04-08 DOI:10.1016/j.lfs.2025.123628

Renhan Liu, Yue Xi, Xinyan Duan, Yifei Zhao, Zhenjun Tian

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引用次数: 0

摘要

心血管疾病会损害远端器官的结构和功能，包括肝脏、骨骼肌、肾脏和脂肪组织。运动能刺激心血管系统和远端器官之间的相互作用，这对疾病康复和器官健康非常重要。然而，运动通过外激介导的器官串联改善心血管功能的机制仍未完全阐明。我们以心血管、运动、外激素、骨骼肌、肝脏、肾脏和脂肪组织为关键词检索相关文章，梳理了不同运动类型之间的差异，总结了17种外激素的功能，重点回顾并归类了心血管系统与远端器官之间相互作用的分子机制。我们还展望了运动预防和控制慢性代谢性疾病的未来研究前景。本综述旨在为制定心血管系统疾病的临床康复和运动处方提供新的理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exerkine-mediated organ interactions: A new interpretation of exercise on cardiovascular function improvement

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Exerkine-mediated organ interactions: A new interpretation of exercise on cardiovascular function improvement

Cardiovascular diseases impair the structure and function of distal organs, including the liver, skeletal muscle, kidney, and adipose tissue. Exercise stimulates the interaction between the cardiovascular system and distal organs that is important for disease rehabilitation and organ health. However, the mechanisms by which exercise improves cardiovascular function through exerkine-mediated organ crosstalk remain incompletely elucidated. We used cardiovascular, exercise, exerkines, skeletal muscle, liver, kidney, and adipose tissue as keywords to search for the relevant articles, sorted out the differences between different exercise types, summarized the functions of 17 exerkines, focused on reviewing and categorizing the molecular mechanisms of interactions between the cardiovascular system and remote organs. We also look forward to future research perspectives on exercise prevention and control of chronic metabolic diseases. The aim of this review is to provide a new theoretical basis for establishing clinical rehabilitation and exercise prescriptions for cardiovascular system diseases.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.