Garcinia yunnanensis的两个联苯二聚体——Garcinia diphenyl A和B

IF 5 1区 化学 Q1 CHEMISTRY, ORGANIC
Sha Wang, Shuangyu Liu, Shuo Wang, Shuqi Wang, Wanhao Feng, Tao Shen, Qingwen Hu, Xiaoning Wang* and Dongmei Ren*, 
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引用次数: 0

摘要

从云南藤黄中分离到两对联苯二聚体garciyndiphenyl A和B[(±)-1和(±)-2]。这些化合物是联苯二聚体的复杂多环笼状骨架的第一个例子。通过综合光谱分析、x射线晶体学和电子圆二色性(ECD)计算确定了它们的结构和绝对构型。此外,还提出了化合物1和2的生物合成途径。两种化合物在人肺癌细胞中均表现出潜在的抗迁移和抗侵袭作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Garciyndiphenyls A and B, Two Biphenyl Dimers with a Caged Skeleton from Garcinia yunnanensis

Garciyndiphenyls A and B, Two Biphenyl Dimers with a Caged Skeleton from Garcinia yunnanensis

Two pairs of enantiomers of biphenyl dimers, garciyndiphenyls A and B [(±)-1 and (±)-2], were isolated from Garcinia yunnanensis. These compounds represent the first example of a complex polycyclic caged skeleton of biphenyl dimers. Their structures and absolute configurations were determined through comprehensive spectroscopic analysis, X-ray crystallography, and electronic circular dichroism (ECD) calculations. Additionally, plausible biosynthetic routes for compounds 1 and 2 were proposed. Both compounds exhibited potential antimigration and anti-invasion effects in human lung cancer cells.

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来源期刊
Organic Letters
Organic Letters 化学-有机化学
CiteScore
9.30
自引率
11.50%
发文量
1607
审稿时长
1.5 months
期刊介绍: Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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