Sha Wang, Shuangyu Liu, Shuo Wang, Shuqi Wang, Wanhao Feng, Tao Shen, Qingwen Hu, Xiaoning Wang* and Dongmei Ren*,
{"title":"Garcinia yunnanensis的两个联苯二聚体——Garcinia diphenyl A和B","authors":"Sha Wang, Shuangyu Liu, Shuo Wang, Shuqi Wang, Wanhao Feng, Tao Shen, Qingwen Hu, Xiaoning Wang* and Dongmei Ren*, ","doi":"10.1021/acs.orglett.5c0109310.1021/acs.orglett.5c01093","DOIUrl":null,"url":null,"abstract":"<p >Two pairs of enantiomers of biphenyl dimers, garciyndiphenyls A and B [(±)-<b>1</b> and (±)-<b>2</b>], were isolated from <i>Garcinia yunnanensis</i>. These compounds represent the first example of a complex polycyclic caged skeleton of biphenyl dimers. Their structures and absolute configurations were determined through comprehensive spectroscopic analysis, X-ray crystallography, and electronic circular dichroism (ECD) calculations. Additionally, plausible biosynthetic routes for compounds <b>1</b> and <b>2</b> were proposed. Both compounds exhibited potential antimigration and anti-invasion effects in human lung cancer cells.</p>","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"27 14","pages":"3800–3805 3800–3805"},"PeriodicalIF":5.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Garciyndiphenyls A and B, Two Biphenyl Dimers with a Caged Skeleton from Garcinia yunnanensis\",\"authors\":\"Sha Wang, Shuangyu Liu, Shuo Wang, Shuqi Wang, Wanhao Feng, Tao Shen, Qingwen Hu, Xiaoning Wang* and Dongmei Ren*, \",\"doi\":\"10.1021/acs.orglett.5c0109310.1021/acs.orglett.5c01093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Two pairs of enantiomers of biphenyl dimers, garciyndiphenyls A and B [(±)-<b>1</b> and (±)-<b>2</b>], were isolated from <i>Garcinia yunnanensis</i>. These compounds represent the first example of a complex polycyclic caged skeleton of biphenyl dimers. Their structures and absolute configurations were determined through comprehensive spectroscopic analysis, X-ray crystallography, and electronic circular dichroism (ECD) calculations. Additionally, plausible biosynthetic routes for compounds <b>1</b> and <b>2</b> were proposed. Both compounds exhibited potential antimigration and anti-invasion effects in human lung cancer cells.</p>\",\"PeriodicalId\":54,\"journal\":{\"name\":\"Organic Letters\",\"volume\":\"27 14\",\"pages\":\"3800–3805 3800–3805\"},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.orglett.5c01093\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.orglett.5c01093","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Garciyndiphenyls A and B, Two Biphenyl Dimers with a Caged Skeleton from Garcinia yunnanensis
Two pairs of enantiomers of biphenyl dimers, garciyndiphenyls A and B [(±)-1 and (±)-2], were isolated from Garcinia yunnanensis. These compounds represent the first example of a complex polycyclic caged skeleton of biphenyl dimers. Their structures and absolute configurations were determined through comprehensive spectroscopic analysis, X-ray crystallography, and electronic circular dichroism (ECD) calculations. Additionally, plausible biosynthetic routes for compounds 1 and 2 were proposed. Both compounds exhibited potential antimigration and anti-invasion effects in human lung cancer cells.
期刊介绍:
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.