非酒精性脂肪性肝病相关肝细胞癌的超声造影特征

IF 2.4 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Ultrasonography Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI:10.14366/usg.24205
Yi Dong, Juan Cheng, Yun-Lin Huang, Yi-Jie Qiu, Jia-Ying Cao, Xiu-Yun Lu, Wen-Ping Wang, Kathleen Möller, Christoph F Dietrich
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引用次数: 0

摘要

目的:探讨非酒精性脂肪性肝病(NAFLD)患者肝细胞癌(HCC)的超声超声造影(Sonazoid- ceus)特征。方法:在这项回顾性研究中,接受手术切除并经组织病理学诊断为NAFLD或肝硬化相关HCC的患者被纳入研究对象。所有患者均于肝手术前1周内接受索那唑-超声造影检查。根据现行的世界超声医学和生物学联合会指南,评估和比较两组之间HCC病变的增强模式。采用多变量logistic回归分析评估索那唑-超声造影增强模式与临床病理特征之间的相关性。结果:从2022年3月至2023年4月,共纳入151例HCC患者,其中nafld相关HCC 72例,乙型肝炎病毒(HBV)肝硬化相关HCC 79例。在Sonazoid-CEUS中,超过一半的nafld相关hcc在60秒内表现出相对早期和轻度的洗脱(54.2%,39/72),而大多数HBV肝硬化相关hcc在60 - 120秒(46.8%,37/79)或120秒后显示洗脱(39.2%,31/79)(P<0.001)。在nafld相关HCC患者中,多因素分析显示,国际标准化比(优势比[OR], 0.002;95%置信区间[CI], 0.000 ~ 0.899;P=0.046)和肿瘤分化差(OR, 21.930;95% CI, 1.960 ~ 245.319;P=0.012)与60秒内发生的洗脱显著相关。结论:Sonazoid-CEUS特征性特征对NAFLD患者HCC的诊断有价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of non-alcoholic fatty liver disease-related hepatocellular carcinoma on contrast-enhanced ultrasound with Sonazoid.

Purpose: This study aimed to evaluate the contrast-enhanced ultrasound with Sonazoid (Sonazoid-CEUS) features of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD).

Methods: In this retrospective study, patients who underwent surgical resection and were histopathologically diagnosed with NAFLD or cirrhosis-related HCC were included. All patients received Sonazoid-CEUS examinations within 1 week prior to hepatic surgery. The enhancement patterns of HCC lesions were evaluated and compared between the two groups according to the current World Federation for Ultrasound in Medicine and Biology guidelines. Multivariate logistic regression analysis was used to assess the correlations between Sonazoid-CEUS enhancement patterns and clinicopathologic characteristics.

Results: From March 2022 to April 2023, a total of 151 patients with HCC were included, comprising 72 with NAFLD-related HCC and 79 with hepatitis B virus (HBV) cirrhosis-related HCC. On Sonazoid-CEUS, more than half of the NAFLD-related HCCs exhibited relatively early and mild washout within 60 seconds (54.2%, 39/72), whereas most HBV cirrhosis-related HCCs displayed washout between 60 and 120 seconds (46.8%, 37/79) or after 120 seconds (39.2%, 31/79) (P<0.001). In the patients with NAFLD-related HCC, multivariate analysis revealed that international normalized ratio (odds ratio [OR], 0.002; 95% confidence interval [CI], 0.000 to 0.899; P=0.046) and poor tumor differentiation (OR, 21.930; 95% CI, 1.960 to 245.319; P=0.012) were significantly associated with washout occurring within 60 seconds.

Conclusion: Characteristic Sonazoid-CEUS features are useful for diagnosing HCC in patients with NAFLD.

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来源期刊
Ultrasonography
Ultrasonography Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.10
自引率
6.50%
发文量
78
审稿时长
15 weeks
期刊介绍: Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content. Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.
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