环丙酚的药理作用机制及临床应用。

IF 4.4 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Frontiers in Pharmacology Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.3389/fphar.2025.1572112
Jianshun Zhou, Lifeng Wang, Zhaoying Zhong, Lei Yuan, Jinhua Huang, Ping Zou, Xiaohui Cao, Donglan Peng, Baozhen Liao, Jianqiang Zeng
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引用次数: 0

摘要

异丙酚具有镇静效果好、起效快、代谢快等优点,已成为临床上最常用的麻醉剂之一。然而,其相关的呼吸和循环抑制和注射疼痛使患者难以忍受。环丙酚在结构上与异丙酚相似,但有一个额外的环丙基,不太可能影响呼吸和循环功能,引起注射疼痛,突出了其临床应用潜力。目前,环丙酚的研究仍处于探索阶段,其作用机制尚不完全清楚,限制了其临床应用。本文就异丙酚的药理作用机制进行综述,对环丙酚的主要药理作用和潜在不良反应进行假设,并对其临床应用现状进行总结,以期为今后的临床应用提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmacological mechanism and clinical application of ciprofol.

Propofol has become one of the most commonly used anesthetic agents because of its good sedative effects, rapid onset, and fast metabolism. However, its associated respiratory and circulatory depression and injection pain make it difficult for patients to tolerate. Ciprofol, which is structurally similar to propofol but has an additional cyclopropyl group, is less likely to impact respiratory and circulatory function and cause injection pain, highlighting its potential for clinical application. Currently, as research on Ciprofol is still in the exploratory stage, its clinical application is limited because its underlying mechanisms are not yet fully understood. The aim of this article is to review the pharmacological mechanisms of propofol, hypothesize the primary pharmacological effects and potential adverse reactions of Ciprofol, and summarize its current clinical application status, with the goal of providing a reference for future clinical use.

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来源期刊
Frontiers in Pharmacology
Frontiers in Pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
7.80
自引率
8.90%
发文量
5163
审稿时长
14 weeks
期刊介绍: Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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