{"title":"环丙酚的药理作用机制及临床应用。","authors":"Jianshun Zhou, Lifeng Wang, Zhaoying Zhong, Lei Yuan, Jinhua Huang, Ping Zou, Xiaohui Cao, Donglan Peng, Baozhen Liao, Jianqiang Zeng","doi":"10.3389/fphar.2025.1572112","DOIUrl":null,"url":null,"abstract":"<p><p>Propofol has become one of the most commonly used anesthetic agents because of its good sedative effects, rapid onset, and fast metabolism. However, its associated respiratory and circulatory depression and injection pain make it difficult for patients to tolerate. Ciprofol, which is structurally similar to propofol but has an additional cyclopropyl group, is less likely to impact respiratory and circulatory function and cause injection pain, highlighting its potential for clinical application. Currently, as research on Ciprofol is still in the exploratory stage, its clinical application is limited because its underlying mechanisms are not yet fully understood. The aim of this article is to review the pharmacological mechanisms of propofol, hypothesize the primary pharmacological effects and potential adverse reactions of Ciprofol, and summarize its current clinical application status, with the goal of providing a reference for future clinical use.</p>","PeriodicalId":12491,"journal":{"name":"Frontiers in Pharmacology","volume":"16 ","pages":"1572112"},"PeriodicalIF":4.4000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975953/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pharmacological mechanism and clinical application of ciprofol.\",\"authors\":\"Jianshun Zhou, Lifeng Wang, Zhaoying Zhong, Lei Yuan, Jinhua Huang, Ping Zou, Xiaohui Cao, Donglan Peng, Baozhen Liao, Jianqiang Zeng\",\"doi\":\"10.3389/fphar.2025.1572112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Propofol has become one of the most commonly used anesthetic agents because of its good sedative effects, rapid onset, and fast metabolism. However, its associated respiratory and circulatory depression and injection pain make it difficult for patients to tolerate. Ciprofol, which is structurally similar to propofol but has an additional cyclopropyl group, is less likely to impact respiratory and circulatory function and cause injection pain, highlighting its potential for clinical application. Currently, as research on Ciprofol is still in the exploratory stage, its clinical application is limited because its underlying mechanisms are not yet fully understood. The aim of this article is to review the pharmacological mechanisms of propofol, hypothesize the primary pharmacological effects and potential adverse reactions of Ciprofol, and summarize its current clinical application status, with the goal of providing a reference for future clinical use.</p>\",\"PeriodicalId\":12491,\"journal\":{\"name\":\"Frontiers in Pharmacology\",\"volume\":\"16 \",\"pages\":\"1572112\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975953/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fphar.2025.1572112\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fphar.2025.1572112","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Pharmacological mechanism and clinical application of ciprofol.
Propofol has become one of the most commonly used anesthetic agents because of its good sedative effects, rapid onset, and fast metabolism. However, its associated respiratory and circulatory depression and injection pain make it difficult for patients to tolerate. Ciprofol, which is structurally similar to propofol but has an additional cyclopropyl group, is less likely to impact respiratory and circulatory function and cause injection pain, highlighting its potential for clinical application. Currently, as research on Ciprofol is still in the exploratory stage, its clinical application is limited because its underlying mechanisms are not yet fully understood. The aim of this article is to review the pharmacological mechanisms of propofol, hypothesize the primary pharmacological effects and potential adverse reactions of Ciprofol, and summarize its current clinical application status, with the goal of providing a reference for future clinical use.
期刊介绍:
Frontiers in Pharmacology is a leading journal in its field, publishing rigorously peer-reviewed research across disciplines, including basic and clinical pharmacology, medicinal chemistry, pharmacy and toxicology. Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.