尼伏单抗诱导的肝细胞癌大疱性类天疱疮的远程表现。

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Ashley Yoo, Joyce Chen, Vivek Sarma, Cherinne Arundel
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引用次数: 0

摘要

一名70多岁的男性,有不可切除的肝细胞癌(HCC)病史,接受纳武单抗治疗后14个月出现水泡皮疹。活检和直接免疫荧光证实了大疱性类天疱疮(BP)的诊断。BP是一种自身免疫性皮肤病,其自身抗体与真皮-表皮交界处结合。这是一种罕见的程序性细胞死亡蛋白-1 (PD-1)抑制剂的后遗症,可以在治疗开始后发展,通常在停药后很快消退。大多数病例报告为黑色素瘤和非小细胞肺癌,很少发生HCC,无论发病时间如何。我们描述了一种罕见的在HCC中使用PD-1抑制剂的远程BP。PD-1抑制剂诱导的BP是一种罕见的皮肤免疫相关不良事件,该病例突出了发病和慢性的可变性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Remote presentation of nivolumab-induced bullous pemphigoid in hepatocellular carcinoma.

A man in his 70s with a history of unresectable hepatocellular carcinoma (HCC) treated with nivolumab presented with a blistering rash 14 months after nivolumab initiation. Biopsies and direct immunofluorescence confirmed the diagnosis of bullous pemphigoid (BP). BP is an autoimmune skin disorder in which autoantibodies bind to the dermal-epidermal junction. It is a rare sequela of programmed cell death protein-1 (PD-1) inhibitors that can develop after treatment initiation and typically resolve soon after discontinuation. Most cases are reported in melanoma and non-small cell lung cancers, and rarely in HCC irrespective of the timing of onset. We describe a rare presentation of remote BP with PD-1 inhibitor use in HCC. PD-1 inhibitor-induced BP is a rare cutaneous immune-related adverse event, and this case highlights the variability in onset and chronicity.

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来源期刊
BMJ Case Reports
BMJ Case Reports Medicine-Medicine (all)
CiteScore
1.40
自引率
0.00%
发文量
1588
期刊介绍: BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.
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