{"title":"间充质干细胞来源的细胞外小泡对帕金森病的抗炎和抗氧化作用。","authors":"Ling Hu, Shaogang Qu","doi":"10.1021/acschemneuro.5c00157","DOIUrl":null,"url":null,"abstract":"<p><p>Oxidative stress and neuroinflammation can synergistically accelerate dopaminergic neuronal degeneration in Parkinson's disease (PD). Small extracellular vesicles derived from mesenchymal stem cells (MSC-sEVs) inhibit Nox4/ROS production by delivering specific miRNAs, regulate the EGR1/NOX4/p38MAPK axis to exert antioxidant effects, and can enhance antioxidant capacity by activating the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Additionally, at the same time, neuroinflammation can be alleviated by inhibiting the Sp1 signal and regulating pro-inflammatory/anti-inflammatory factors. MSC-sEVs can penetrate the blood-brain barrier, improve movement disorders, and relieve neuronal damage in PD models, providing a new anti-inflammatory and antioxidant strategy for PD treatment.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-inflammatory and Antioxidant Effects of Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Derived from Mesenchymal Stem Cells on Parkinson's Disease.\",\"authors\":\"Ling Hu, Shaogang Qu\",\"doi\":\"10.1021/acschemneuro.5c00157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Oxidative stress and neuroinflammation can synergistically accelerate dopaminergic neuronal degeneration in Parkinson's disease (PD). Small extracellular vesicles derived from mesenchymal stem cells (MSC-sEVs) inhibit Nox4/ROS production by delivering specific miRNAs, regulate the EGR1/NOX4/p38MAPK axis to exert antioxidant effects, and can enhance antioxidant capacity by activating the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Additionally, at the same time, neuroinflammation can be alleviated by inhibiting the Sp1 signal and regulating pro-inflammatory/anti-inflammatory factors. MSC-sEVs can penetrate the blood-brain barrier, improve movement disorders, and relieve neuronal damage in PD models, providing a new anti-inflammatory and antioxidant strategy for PD treatment.</p>\",\"PeriodicalId\":13,\"journal\":{\"name\":\"ACS Chemical Neuroscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Chemical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1021/acschemneuro.5c00157\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Chemical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1021/acschemneuro.5c00157","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Anti-inflammatory and Antioxidant Effects of Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Derived from Mesenchymal Stem Cells on Parkinson's Disease.
Oxidative stress and neuroinflammation can synergistically accelerate dopaminergic neuronal degeneration in Parkinson's disease (PD). Small extracellular vesicles derived from mesenchymal stem cells (MSC-sEVs) inhibit Nox4/ROS production by delivering specific miRNAs, regulate the EGR1/NOX4/p38MAPK axis to exert antioxidant effects, and can enhance antioxidant capacity by activating the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Additionally, at the same time, neuroinflammation can be alleviated by inhibiting the Sp1 signal and regulating pro-inflammatory/anti-inflammatory factors. MSC-sEVs can penetrate the blood-brain barrier, improve movement disorders, and relieve neuronal damage in PD models, providing a new anti-inflammatory and antioxidant strategy for PD treatment.
期刊介绍：
ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following:
Neurotransmitters and receptors
Neuropharmaceuticals and therapeutics
Neural development—Plasticity, and degeneration
Chemical, physical, and computational methods in neuroscience
Neuronal diseases—basis, detection, and treatment
Mechanism of aging, learning, memory and behavior
Pain and sensory processing
Neurotoxins
Neuroscience-inspired bioengineering
Development of methods in chemical neurobiology
Neuroimaging agents and technologies
Animal models for central nervous system diseases
Behavioral research
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