慢性阻塞性肺疾病的脂质代谢重编程。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Qianqian Liang, Yide Wang, Zheng Li
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引用次数: 0

摘要

慢性阻塞性肺疾病(COPD)是一种复杂多样的呼吸系统疾病,以持续的呼吸道症状和气流受限为特征。主要临床表现包括慢性咳嗽、咳痰和喘息。主要的病理特征包括炎症细胞的浸润、粘液的过量产生和肺泡壁的损伤。慢性阻塞性肺病的根本原因是复杂的,尚未完全阐明,被认为是多种因素共同作用的结果。脂质作为疏水分子,具有能量储存、膜生物合成和信号转导三种基本功能。脂质代谢与多种代谢途径错综复杂地交织在一起,在COPD复杂的发病机制中起着关键作用。深入研究脂质代谢,以及脂质分子在细胞中的特殊修饰和作用,在COPD的背景下是至关重要的。这篇综述的主要目的是阐明脂肪酸代谢在COPD发病和进展中的作用。此外,它还研究了脂质代谢重编程作为一种有前途的治疗方法的潜力,为这种致残呼吸系统疾病的管理和治疗指明了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid metabolism reprogramming in chronic obstructive pulmonary disease.

Chronic Obstructive Pulmonary Disease (COPD) is a complex and diverse respiratory disorder, characterized by ongoing respiratory symptoms and restricted airflow. The major clinical manifestations typically encompass chronic cough, sputum production, and wheezing. The main pathological characteristics involve infiltration of inflammatory cells, overproduction of mucus, and damage to the alveolar walls. The underlying causes of COPD are complex and remain incompletely elucidated, thought to originate from the combined effect of various factors. Lipids, as hydrophobic molecules, fulfill three fundamental functions: energy storage, membrane biosynthesis, and signal transduction. Lipid metabolism is intricately intertwined with various metabolic pathways and plays a pivotal role in the complex pathogenesis of COPD. Delving into lipid metabolism, as well as the particular modifications and roles of lipid molecules in cells, is of paramount importance in the context of COPD. This review primarily aims to elucidate the role of fatty acid metabolism in the onset and progression of COPD. Additionally, it examines the potential of lipid metabolism reprogramming as a promising therapeutic approach, illuminating new paths for the management and treatment of this disabling respiratory condition.

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来源期刊
Molecular Medicine
Molecular Medicine 医学-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
137
审稿时长
1 months
期刊介绍: Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.
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