精神分裂症谱系障碍较高的血脑屏障渗漏：与健康对照的动态对比增强磁共振成像研究

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-04-05 DOI:10.1016/j.bbi.2025.04.003

Joanna Moussiopoulou , Vladislav Yakimov , Lukas Roell , Boris-Stephan Rauchmann , Hannah Toth , Julian Melcher , Iris Jäger , Isabel Lutz , Marcel S. Kallweit , Boris Papazov , Emanuel Boudriot , Klaus Seelos , Amir Dehsarvi , Mattia Campana , Florian Raabe , Isabel Maurus , Lisa Löhrs , Matthias Brendel , Sophia Stöcklein , Peter Falkai , Elias Wagner

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引用次数: 0

摘要

背景：血脑屏障（BBB）破坏被认为与精神分裂症谱系障碍（ssd）有关。以前的研究主要集中在脑脊液（CSF）标记物上，这对于检测细微的血脑屏障破坏是不精确的。动态对比增强磁共振成像（DCE-MRI）能够对体内细微血脑屏障泄漏进行敏感调查，但在SSD研究中仍未得到探索。我们假设与健康对照（hc）相比，ssd的渗漏率更高，这表明存在临床亚表型。方法：采用DCE-MRI、临床特征、认知评估、血液和脑脊液分析，将41名ssd患者和40名年龄和性别匹配的hc患者纳入本横断面研究。采用Patlak方法计算体积传递常数Ktrans，以估计对比剂在血液和血管外空间之间的传递，比较两组之间血脑屏障泄漏的差异。结果：与hc患者相比，ssd患者的血脑屏障泄漏程度更高，其分布范围更广，在ssd患者通常受影响的大脑区域。渗漏与认知、症状严重程度、外周炎症标志物和白蛋白CSF/血清比值之间无显著相关性。结论：这是迄今为止第一个报道与该疾病相关的多个脑区中ssd的血脑屏障泄漏的研究。这些发现提供了对疾病机制的见解，强调了进一步研究血脑屏障在ssd中的作用的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Higher blood–brain barrier leakage in schizophrenia-spectrum disorders: A comparative dynamic contrast-enhanced magnetic resonance imaging study with healthy controls

查看原文本刊更多论文

Higher blood–brain barrier leakage in schizophrenia-spectrum disorders: A comparative dynamic contrast-enhanced magnetic resonance imaging study with healthy controls

Background

Blood-brain barrier (BBB) disruptions are presumed to be implicated in schizophrenia-spectrum disorders (SSDs). Previous studies focused on cerebrospinal fluid (CSF) markers, which are imprecise for detecting subtle BBB disruption. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables sensitive investigation of subtle BBB leakage in vivo, yet remains unexplored in SSD research. We hypothesized higher leakage in SSDs compared to healthy controls (HCs), indicating a clinical sub-phenotype.

Methods

Forty-one people with SSDs and forty age- and sex-matched HCs were included in this cross-sectional study employing DCE-MRI, clinical characterization, cognitive assessment, blood and CSF analyses. The volume transfer constant K_trans, calculated using the Patlak method to estimate the contrast agent transfer between blood and extravascular space, was compared between groups to detect differences in BBB leakage.

Results

Individuals with SSDs showed higher BBB leakage compared to HCs in a widespread pattern, in brain regions typically affected in SSDs. No significant association was detected between leakage and measures of cognition, symptom severity, peripheral inflammation markers and albumin CSF/serum ratio.

Conclusions

This is the first study to date reporting BBB leakage in SSDs compared to HCs in multiple brain regions implicated in the disorder. These findings provide insights into disease mechanisms, highlighting the need for further investigation into the role of the BBB in SSDs.

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.