睾丸癌幸存者中的骨质疏松症：退伍军人事务卫生系统的长期随访

IF 2.3 3区医学 Q3 ONCOLOGY

Clinical genitourinary cancer Pub Date : 2025-03-19 DOI:10.1016/j.clgc.2025.102332

Nuphat Yodkhunnatham , Paul Riviere , Kshitij Pandit , Kylie Morgan , Margaret Meagher , Mai Dabbas , Tyler Nelson , Dhruv Puri , Kit Yuen , Jacob Taylor , Daniel Herchenhorn , Heather Hofflich , Tyler Stewart , Juan Javier-Desloges , Amirali Salmasi , Rana R. McKay , Sean Q. Kern , Frederick Millard , Brent Rose , Aditya Bagrodia

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引用次数: 0

摘要

睾丸癌（TC）是年轻男性中最常见的恶性肿瘤，治愈率超过95%。然而，治疗的长期健康影响，如骨质疏松症的风险，仍然没有充分了解。本研究旨在探讨TC幸存者骨质疏松的发生率及相关危险因素。方法本回顾性研究利用退伍军人事务（VA）国家电子健康记录系统的数据，确定1686例TC患者和7412例匹配的非癌症对照。通过诊断代码和骨质疏松药物处方确定骨质疏松发生率。采用统计学分析，包括卡方检验、t检验和Cox比例风险模型来评估危险因素。结果stc幸存者发生骨质疏松的风险显著升高(HR =2.18；95% ci, 1.52-3.14；P & lt;.001)，校正协变量后仍然存在(HR = 1.58；95% ci, 0.99-2.51；P = .013)。在多变量分析中，没有明显的TC治疗特异性效应：放疗和化疗均与骨质疏松风险增加无关。结论tc患者发生骨质疏松的风险较高，诊断年龄是一个重要因素。这些发现强调了对TC幸存者进行定期骨健康监测的必要性。未来的前瞻性研究需要验证这些结果，并更好地了解TC、性腺功能减退和骨质疏松风险之间的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Osteoporosis Amongst Testicular Cancer Survivors: Long Term Follow-Up of the Veterans Affairs Health System

Introduction

Testicular cancer (TC) is the most common malignancy among young males and is associated with cure rates over 95%. However, the long-term health implications of treatments, such as the risk of osteoporosis, remain inadequately understood. This study aims to explore the incidence of osteoporosis in TC survivors and associated risk factors.

Methods

This retrospective study utilized data from the Veterans Affairs (VA) national electronic health record system, identifying 1686 TC patients and 7412 matched noncancer controls. The incidence of osteoporosis was determined through diagnosis codes and osteoporosis medication prescriptions. Statistical analyses, including chi-squared tests, t-tests, and Cox proportional hazards models, were employed to evaluate risk factors.

Results

TC survivors exhibited a significantly elevated hazard of developing osteoporosis (HR =2.18; 95% CI, 1.52-3.14; P < .001), which persisted after adjusting for covariates (HR = 1.58; 95% CI, 0.99-2.51; P = .013). There was no significant TC treatment-specific effect: neither radiation nor chemotherapy were associated with an increased hazard of osteoporosis in multivariable analysis.

Conclusion

TC survivors face a higher hazard of osteoporosis, with age at diagnosis being a significant factor. These findings highlight the need for regular bone health monitoring in TC survivors. Future prospective studies are necessary to validate these results and better understand the mechanisms linking TC, hypogonadism, and osteoporosis risk.

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来源期刊

Clinical genitourinary cancer 医学-泌尿学与肾脏学

CiteScore

5.20

自引率

6.20%

发文量

201

审稿时长

54 days

期刊介绍： Clinical Genitourinary Cancer is a peer-reviewed journal that publishes original articles describing various aspects of clinical and translational research in genitourinary cancers. Clinical Genitourinary Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of genitourinary cancers. The main emphasis is on recent scientific developments in all areas related to genitourinary malignancies. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.