Jerome Jean-Joseph, Nikolaus Balagiannis, Markus W Scheppach, Selin Temizel, Alanna Ebigbo, Helmut Messmann, Tilman Janzen, Georg Stüben
{"title":"用于增强型食道近距离放射治疗器的助熔剂溶液。","authors":"Jerome Jean-Joseph, Nikolaus Balagiannis, Markus W Scheppach, Selin Temizel, Alanna Ebigbo, Helmut Messmann, Tilman Janzen, Georg Stüben","doi":"10.5114/jcb.2025.147780","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>In this study, a novel auxetic applicator equipped with four-channel catheters for esophageal brachytherapy was presented.</p><p><strong>Material and methods: </strong>The applicator, made of a new biocompatible material, has an auxetic helical structure with four channels. Details of applicator modeling, construction, commissioning, and insertion were provided. Initial <i>ex vivo</i> trial conducted on a porcine model was outlined.</p><p><strong>Results: </strong>Simulations and dose calculations closely matched experimental measurements, validating the modeling approach. This applicator achieved highly asymmetric dose distributions. Its unique auxetic helical design allowed smooth insertion, while mitigating sequential inter-fraction hot spot formation.</p><p><strong>Conclusions: </strong><i>Ex vivo</i> implementation of the applicator demonstrated feasibility, resulting in consistent and reproducible dose distributions. Initial outcomes showed promise for the applicator's efficacy and versatility in intra-luminal or intra-cavitary applications.</p>","PeriodicalId":51305,"journal":{"name":"Journal of Contemporary Brachytherapy","volume":"17 1","pages":"33-42"},"PeriodicalIF":1.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966220/pdf/","citationCount":"0","resultStr":"{\"title\":\"Auxetic solution for enhanced esophageal brachytherapy applicator.\",\"authors\":\"Jerome Jean-Joseph, Nikolaus Balagiannis, Markus W Scheppach, Selin Temizel, Alanna Ebigbo, Helmut Messmann, Tilman Janzen, Georg Stüben\",\"doi\":\"10.5114/jcb.2025.147780\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>In this study, a novel auxetic applicator equipped with four-channel catheters for esophageal brachytherapy was presented.</p><p><strong>Material and methods: </strong>The applicator, made of a new biocompatible material, has an auxetic helical structure with four channels. Details of applicator modeling, construction, commissioning, and insertion were provided. Initial <i>ex vivo</i> trial conducted on a porcine model was outlined.</p><p><strong>Results: </strong>Simulations and dose calculations closely matched experimental measurements, validating the modeling approach. This applicator achieved highly asymmetric dose distributions. Its unique auxetic helical design allowed smooth insertion, while mitigating sequential inter-fraction hot spot formation.</p><p><strong>Conclusions: </strong><i>Ex vivo</i> implementation of the applicator demonstrated feasibility, resulting in consistent and reproducible dose distributions. Initial outcomes showed promise for the applicator's efficacy and versatility in intra-luminal or intra-cavitary applications.</p>\",\"PeriodicalId\":51305,\"journal\":{\"name\":\"Journal of Contemporary Brachytherapy\",\"volume\":\"17 1\",\"pages\":\"33-42\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966220/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Contemporary Brachytherapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/jcb.2025.147780\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Contemporary Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/jcb.2025.147780","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Auxetic solution for enhanced esophageal brachytherapy applicator.
Purpose: In this study, a novel auxetic applicator equipped with four-channel catheters for esophageal brachytherapy was presented.
Material and methods: The applicator, made of a new biocompatible material, has an auxetic helical structure with four channels. Details of applicator modeling, construction, commissioning, and insertion were provided. Initial ex vivo trial conducted on a porcine model was outlined.
Results: Simulations and dose calculations closely matched experimental measurements, validating the modeling approach. This applicator achieved highly asymmetric dose distributions. Its unique auxetic helical design allowed smooth insertion, while mitigating sequential inter-fraction hot spot formation.
Conclusions: Ex vivo implementation of the applicator demonstrated feasibility, resulting in consistent and reproducible dose distributions. Initial outcomes showed promise for the applicator's efficacy and versatility in intra-luminal or intra-cavitary applications.
期刊介绍:
The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.