用于增强型食道近距离放射治疗器的助熔剂溶液。

IF 1.1 4区 医学 Q4 ONCOLOGY
Journal of Contemporary Brachytherapy Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI:10.5114/jcb.2025.147780
Jerome Jean-Joseph, Nikolaus Balagiannis, Markus W Scheppach, Selin Temizel, Alanna Ebigbo, Helmut Messmann, Tilman Janzen, Georg Stüben
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引用次数: 0

摘要

目的:本研究介绍了一种配备四通道导管的新型辅助涂抹器,用于食道近距离放射治疗:该涂抹器由一种新型生物兼容材料制成,具有辅助螺旋结构和四个通道。详细介绍了涂抹器的建模、构造、调试和插入。此外,还概述了在猪模型上进行的初步体外试验:结果:模拟和剂量计算与实验测量结果非常吻合,验证了建模方法。这种涂抹器实现了高度不对称的剂量分布。其独特的辅助螺旋设计允许顺利插入,同时减少了连续的分段间热点的形成:结论:在体内外使用这种涂抹器证明了其可行性,可实现一致且可重复的剂量分布。初步结果表明,该涂抹器在腔内或腔内应用中具有良好的疗效和多功能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Auxetic solution for enhanced esophageal brachytherapy applicator.

Purpose: In this study, a novel auxetic applicator equipped with four-channel catheters for esophageal brachytherapy was presented.

Material and methods: The applicator, made of a new biocompatible material, has an auxetic helical structure with four channels. Details of applicator modeling, construction, commissioning, and insertion were provided. Initial ex vivo trial conducted on a porcine model was outlined.

Results: Simulations and dose calculations closely matched experimental measurements, validating the modeling approach. This applicator achieved highly asymmetric dose distributions. Its unique auxetic helical design allowed smooth insertion, while mitigating sequential inter-fraction hot spot formation.

Conclusions: Ex vivo implementation of the applicator demonstrated feasibility, resulting in consistent and reproducible dose distributions. Initial outcomes showed promise for the applicator's efficacy and versatility in intra-luminal or intra-cavitary applications.

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来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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