心力衰竭患者肾功能调整后肌钙蛋白水平的预后价值--系统性综述。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Anca Breha, Caterina Delcea, Andreea Cristina Ivanescu, Gheorghe Andrei Dan
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引用次数: 0

摘要

心力衰竭(HF)是一个重要的全球健康问题,与高发病率和死亡率相关。准确的生物标志物对于预测不良后果和告知管理至关重要。高敏感性心肌肌钙蛋白T (hs-cTnT)和I (hs-cTnI)是心衰的重要预后指标,尽管它们的预测价值可能受到合并症,特别是肾功能不全的影响。目的:本综述评价肌钙蛋白对心衰患者肾功能的预后意义。方法:在PubMed中进行全面的文献检索,包括2011年至2024年9月的研究,使用与HF、肌钙蛋白和预后相关的特定MeSH术语。结果:32项研究符合纳入标准,均表明心衰患者肌钙蛋白水平调整后的肾功能与心血管死亡率之间存在关联(HR 1.67-3.22)。高敏感性心肌肌钙蛋白T (hs-cTnT)和I (hs-cTnI)是急性心力衰竭(AHF)心血管死亡率的独立预测因子。hs-cTnI水平升高(基线阈值为0.03 ng/mL)与死亡风险显著相关(P = 0.0011)。调整肾功能后,hs-cTnT患者> 14 ng/L、> 21.5 ng/L和> 26.5 ng/L的全因死亡率增加。尽管存在这些关联,肌钙蛋白在预测心力衰竭再入院中的作用仍然不一致,这表明肌钙蛋白水平升高并不能可靠地预测再住院风险,特别是在那些有晚期肾功能损害的患者中。结论:高敏感性肌钙蛋白(hs-cTnT和hs-cTnI)是心力衰竭死亡率的独立预测因子,即使在考虑肾功能后也是如此,但它们在预测住院率方面的作用较弱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Prognostic Value of Troponin Levels Adjusted for Renal Function in Heart Failure - A Systematic Review.

Introduction: Heart failure (HF) is a significant global health issue associated with high morbidity and mortality. Accurate biomarkers are crucial for predicting adverse outcomes and informing management. High-sensitivity cardiac troponins T (hs-cTnT) and I (hs-cTnI) are important prognostic indicators in HF, though their predictive value can be affected by comorbidities, particularly renal dysfunction.

Objectives: This review evaluates the prognostic significance of troponin adjusted for renal function in patients with HF.

Methods: A comprehensive literature search was performed in PubMed, including studies from 2011 to September 2024, using specific MeSH terms related to HF, troponin, and prognosis.

Results: Thirty-two studies met the inclusion criteria, all indicating an association between troponin levels adjusted for renal function and cardiovascular mortality in HF patients (HR 1.67-3.22). High-sensitivity cardiac troponins T (hs-cTnT) and I (hs-cTnI) are independent predictors of cardiovascular mortality in acute heart failure (AHF). Increasing hs-cTnI levels, with a baseline threshold of 0.03 ng/mL, significantly correlate with mortality risk (P = .0011). Patients with hs-cTnT > 14 ng/L, > 21.5 ng/L, and > 26.5 ng/L exhibit increased all-cause mortality after adjusting for renal function. Despite these associations, the role of troponin in predicting heart failure readmissions remains inconsistent, indicating that elevated troponin levels do not reliably predict rehospitalization risk, particularly in those with advanced renal impairment.

Conclusions: High-sensitivity troponins (hs-cTnT and hs-cTnI) are independent predictors of mortality in heart failure, even after accounting for renal function, while their role in predicting hospitalizations is weaker.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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