日本胶质瘤队列中分子胶质母细胞瘤的临床、组织学和基因组信息分析。

IF 2.7 3区 医学 Q2 CLINICAL NEUROLOGY
Ryutaro Makino, Madan Bajagain, Nayuta Higa, Toshiaki Akahane, Hajime Yonezawa, Hiroyuki Uchida, Tomoko Takajo, Mari Kirishima, Seiya Yokoyama, Ryosuke Otsuji, Yutaka Fujioka, Daisuke Kuga, Hitoshi Yamahata, Masamichi Kurosaki, Junkoh Yamamoto, Koji Yoshimoto, Akihide Tanimoto, Ryosuke Hanaya
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引用次数: 0

摘要

在2021年WHO中枢神经系统肿瘤分类中,“胶质母细胞瘤,IDH-wildtype”的诊断发生了明显变化。在一项日本队列研究中,我们比较了分子胶质母细胞瘤(mGBM)和常规胶质母细胞瘤(组织学胶质母细胞瘤,hGBM)的临床背景和预后。我们纳入了2011-2023年间在5家机构治疗的270例胶质母细胞瘤患者。使用脑肿瘤特异性定制基因面板进行驱动基因分析,以验证分子和临床信息之间的关联。与hGBM患者相比,mGBM患者术前KPS更好,Ki-67更低,切除率更低。mGBM患者的总生存期长于hGBM患者(1207天vs 599天,p = 0.037)。TP53突变(风险比:5.33,95%可信区间:0.26-108.7,p = 0.012)和组织学分级3 (p = 0.051)是mGBM预后不良的因素。与hGBM患者相比,mGBM患者术前KPS更好,去除率更差,Ki-67标记指数更低,总生存率更高。此外,mGBM的组织学分级可能有助于估计预后。在WHO CNS5 2021中,胶质母细胞瘤患者仍然是一个异质性人群,基于患者临床背景和分子信息的预后分层是可取的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of clinical, histological, and genomic information of molecular glioblastoma in a Japanese glioma cohort.

In the 2021 WHO Central Nervous System tumor classification, the "Glioblastoma, IDH-wildtype" diagnosis changed markedly. In a Japanese cohort, we compared the clinical backgrounds and prognoses of molecular glioblastoma (mGBM) and conventional glioblastoma (histological glioblastoma, hGBM). We included 270 patients with glioblastoma treated at five institutions during 2011-2023. Driver gene analysis was performed using a brain tumor-specific custom gene panel to verify the association between molecular and clinical information. Patients with mGBM had better preoperative KPS, lower Ki-67, and lower removal rates than did those with hGBM. Overall survival was longer in patients with mGBM than in those with hGBM (1207 vs 599 days, p = 0.037). TP53 mutation (hazard ratio: 5.33, 95% confidence interval: 0.26-108.7, p = 0.012) and histological grade 3 (p = 0.051) were poor prognostic factors for mGBM. Patients with mGBM had better preoperative KPS, worse removal rates, lower Ki-67 labeling index, and better overall survival than did those with hGBM. In addition, the histological grade of mGBM is potentially useful for estimating prognosis. In the WHO CNS5 2021, glioblastoma patients remain a heterogeneous population, and prognostic stratification based on the patient's clinical background and molecular information is desirable.

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来源期刊
Brain Tumor Pathology
Brain Tumor Pathology 医学-病理学
CiteScore
5.40
自引率
9.10%
发文量
30
审稿时长
>12 weeks
期刊介绍: Brain Tumor Pathology is the official journal of the Japan Society of Brain Tumor Pathology. This international journal documents the latest research and topical debate in all clinical and experimental fields relating to brain tumors, especially brain tumor pathology. The journal has been published since 1983 and has been recognized worldwide as a unique journal of high quality. The journal welcomes the submission of manuscripts from any country. Membership in the society is not a prerequisite for submission. The journal publishes original articles, case reports, rapid short communications, instructional lectures, review articles, letters to the editor, and topics.Review articles and Topics may be recommended at the annual meeting of the Japan Society of Brain Tumor Pathology. All contributions should be aimed at promoting international scientific collaboration.
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