从CRISPR屏幕到电路：识别T细胞激活和状态转换的关键调节因子

IF 40.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Signal Transduction and Targeted Therapy Pub Date : 2025-04-07 DOI:10.1038/s41392-025-02200-3

Maria Silvia Roman Azcona, Toni Cathomen, Claudio Mussolino

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引用次数: 0

摘要

Maya M. Arce及其同事最近发表在《自然》杂志上的一项研究揭示了中心基因回路在控制T细胞休息和T细胞激活之间微妙平衡中的作用这项工作将基础分子生物学与临床前模型的发现联系起来，为特定环境的基因调控和免疫调节的潜在治疗靶点提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

From CRISPR screens to circuits: identifying key regulators in T cell activation and state transitions

查看原文本刊更多论文

From CRISPR screens to circuits: identifying key regulators in T cell activation and state transitions

A recent study published in Nature by Maya M. Arce and colleagues unveils the role of central gene circuits in governing the delicate balance between T cell rest and T cell activation.¹ This work bridges fundamental molecular biology with findings in preclinical models, providing insights into context-specific gene regulation and potential therapeutic targets for immune modulation.

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来源期刊

Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

44.50

自引率

1.50%

发文量

384

审稿时长

5 weeks

期刊介绍： Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.