靶向B4GALT3的bmscs - ev通过抑制NF-κB通路治疗控制HCC。

IF 5.3 2区医学 Q2 CELL BIOLOGY

Cell Biology and Toxicology Pub Date : 2025-04-05 DOI:10.1007/s10565-025-10013-x

Juncheng Guo, Kaiqiong Wang, Qigang Sun, Jun Liu, Jinfang Zheng

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引用次数: 0

摘要

研究肝细胞癌（HCC）特异性肿瘤微环境（TME）中的通讯，本研究探讨了骨髓间充质基质细胞衍生的细胞外囊泡（bmscs - ev）中β -1,4-半乳酸转移酶III （B4GALT3）在NF-κB通路和癌症相关成纤维细胞（CAF）的触发中所起的作用。本研究通过转录组测序、生物信息学分析和多种实验模型相结合的多学科方法，揭示了B4GALT3通过调节NF-κB信号通路参与CAF活性的调节。结果表明，靶向B4GALT3可抑制HCC细胞的迁移和侵袭，促进细胞凋亡，抑制肿瘤的进展和转移，为HCC的潜在治疗策略提供了新的见解。

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Targeting B4GALT3 in BMSCs-EVs for Therapeutic Control of HCC via NF-κB pathway inhibition.

Examining the communications in the tumor microenvironment (TME) specific to hepatocellular carcinoma (HCC), this exploration looks into the role played by beta-1,4-Galactosyltransferase III (B4GALT3) in bone marrow mesenchymal stromal cell-derived extracellular vesicles (BMSCs-EVs) regarding the NF-κB pathway and the triggering of cancer-associated fibroblasts (CAF). Through a multidisciplinary approach combining transcriptome sequencing, bioinformatic analysis, and various experimental models, the involvement of B4GALT3 in regulating CAF activity by modulating NF-κB signaling was brought to light in our study. The outcomes suggest that targeting B4GALT3 could impede HCC cell migration and invasion, promote apoptosis, and dampen tumor progression and metastasis, offering novel insights into potential therapeutic strategies for combating HCC.

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来源期刊

Cell Biology and Toxicology 生物-毒理学

CiteScore

9.90

自引率

4.90%

发文量

101

审稿时长

>12 weeks

期刊介绍： Cell Biology and Toxicology (CBT) is an international journal focused on clinical and translational research with an emphasis on molecular and cell biology, genetic and epigenetic heterogeneity, drug discovery and development, and molecular pharmacology and toxicology. CBT has a disease-specific scope prioritizing publications on gene and protein-based regulation, intracellular signaling pathway dysfunction, cell type-specific function, and systems in biomedicine in drug discovery and development. CBT publishes original articles with outstanding, innovative and significant findings, important reviews on recent research advances and issues of high current interest, opinion articles of leading edge science, and rapid communication or reports, on molecular mechanisms and therapies in diseases.