基于多组学整合分析的脂溢性皮炎与头皮银屑病的关系及诊断靶点探索

IF 2.6 3区生物学 Q2 GENETICS & HEREDITY

Gene Pub Date : 2025-04-03 DOI:10.1016/j.gene.2025.149441

Li Yang , Yunying Wang , Yiya Zhang , Yisheng Cai , Zhihua Fan , Fangfen Liu

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引用次数: 0

摘要

头皮脂溢性皮炎（SD）和牛皮癣（PSO）是常见的慢性皮肤病，临床表现重叠，特别是当局限于头皮时，这使鉴别诊断复杂化。本研究结合转录组学分析和遗传关联分析来研究SD和头皮PSO之间的潜在因果关系。通过对SD和头皮PSO患者以及健康对照者的病变性和非病变性头皮样本进行RNA测序，我们发现脂溢性皮炎可能是进展为头皮PSO的危险因素。此外，TGM1和IL36RN被确定为区分脂溢性皮炎和头皮PSO的关键潜在分子靶点。

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Exploring the relationship and diagnostic targets of seborrheic dermatitis and scalp psoriasis based on multi-omics integration analysis

Scalp seborrheic dermatitis (SD) and psoriasis (PSO) are prevalent chronic skin conditions with overlapping clinical manifestations, especially when confined to the scalp, which complicates differential diagnosis. This study integrates transcriptomic profiling and genetic association analyses to investigate potential causal links between SD and scalp PSO. Through RNA sequencing on lesional and non-lesional scalp samples from patients with SD and scalp PSO, as well as healthy controls, we found that seborrheic dermatitis may represent a risk factor for the progression to scalp PSO. Furthermore, TGM1 and IL36RN were identified as key potential molecular targets that could differentiate seborrheic dermatitis from scalp PSO.

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来源期刊

Gene 生物-遗传学

CiteScore

6.10

自引率

2.90%

发文量

718

审稿时长

42 days

期刊介绍： Gene publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses.