揭示群体CBT和ACT治疗抑郁症的变化链：一项随机临床试验方案。

IF 2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Contemporary clinical trials Pub Date : 2025-04-02 DOI:10.1016/j.cct.2025.107907

Anh Dao, Rachel A. Bernstein, Francisco N. Ramos, Brittany Beasley, Iony D. Ezawa

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引用次数: 0

摘要

背景：认知行为疗法（CBT）和接受与承诺疗法（ACT）是治疗抑郁症最有效的方法，但它们的疗效仍然有限。先前的研究未能提高这些有效率，部分原因是对这些治疗方法变化过程的了解有限，以及哪些个体可能从不同的治疗过程中或多或少受益。方法：100名诊断为重度抑郁症的成年人将被随机分配接受8周的CBT组（n = 50）或ACT组（n = 50）。我们将使用密集的纵向抽样方法来检查整个治疗过程中治疗技巧的使用、理论化的治疗机制和治疗结果。主要目的是检查理论治疗机制在治疗技能使用和治疗结果之间的关联中的中介作用。我们的第二个目的是检查治疗方式和病人特征对治疗技能使用和改变机制激活之间的关联的综合调节作用。结论：这项工作有可能通过接近“什么对谁有效”的问题，为精确的精神卫生保健提供信息，因为它与数据驱动的抑郁症心理治疗干预有关。试验注册号：该研究注册于www.Clinicaltrials: gov （NCT06245096）。

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Unpacking the chain of change in group CBT and ACT for depression: A protocol for a randomized clinical trial

Background

Cognitive behavioral therapy (CBT) and acceptance and commitment therapy (ACT) are among our most effective treatments for depression, yet their efficacy remains modest. Prior research has not been able to improve these efficacy rates in part due to the limited insight into the processes of change in these treatments and which individuals may benefit more or less from different therapeutic processes.

Method

One hundred adults with a diagnosis of major depressive disorder will be randomized to receive eight weeks of group CBT (n = 50) or ACT (n = 50). We will use intensive longitudinal sampling methods to examine therapeutic skills use, theorized treatment mechanisms, and treatment outcomes throughout the course of treatment. The primary aim is to examine the mediational effect of theorized treatment mechanisms on the association between therapeutic skills use and treatment outcomes. Our secondary aim is to examine the combined moderating effects of treatment modality and client characteristics on the association between therapeutic skills use and activation of mechanisms of change.

Conclusion

This work has the potential to inform precision mental health care by closing in on the question of “what works and for whom” as it relates to data-driven psychotherapeutic interventions for depression.

Trial registration number

The study is registered at www.clinicaltrials.gov (NCT06245096).

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来源期刊

Contemporary clinical trials 医学-药学

CiteScore

3.70

自引率

4.50%

发文量

281

审稿时长

44 days

期刊介绍： Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.