LGR信号和代谢调控：解决胰岛素抵抗和糖尿病治疗的新前沿。

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2025-04-05 DOI:10.1111/jdi.70042

Tomohisa Aoyama, Toshimasa Yamauchi

{"title":"LGR信号和代谢调控：解决胰岛素抵抗和糖尿病治疗的新前沿。","authors":"Tomohisa Aoyama, Toshimasa Yamauchi","doi":"10.1111/jdi.70042","DOIUrl":null,"url":null,"abstract":"<p>LGR signaling plays a crucial role in metabolic regulation by coordinating muscle-neuron-adipose tissue crosstalk. In response to a high-sugar diet, muscle-derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity. This evolutionarily conserved pathway underscores LGR4 as a promising therapeutic target for insulin resistance and diabetes.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"16 6","pages":"984-985"},"PeriodicalIF":3.0000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70042","citationCount":"0","resultStr":"{\"title\":\"LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment\",\"authors\":\"Tomohisa Aoyama, Toshimasa Yamauchi\",\"doi\":\"10.1111/jdi.70042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>LGR signaling plays a crucial role in metabolic regulation by coordinating muscle-neuron-adipose tissue crosstalk. In response to a high-sugar diet, muscle-derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity. This evolutionarily conserved pathway underscores LGR4 as a promising therapeutic target for insulin resistance and diabetes.\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":51250,\"journal\":{\"name\":\"Journal of Diabetes Investigation\",\"volume\":\"16 6\",\"pages\":\"984-985\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.70042\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Diabetes Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jdi.70042\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes Investigation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jdi.70042","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

摘要

LGR 信号通过协调肌肉-神经元-脂肪组织之间的串扰，在代谢调节中发挥着至关重要的作用。在高糖饮食的作用下，来自肌肉的 BMP 信号激活神经元 Bursicon，从而刺激胰岛素分泌并增强脂肪对胰岛素的敏感性。这一进化保守的途径突出表明，LGR4 是治疗胰岛素抵抗和糖尿病的一个很有前景的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment

查看原文本刊更多论文

LGR signaling and metabolic regulation: A new frontier in addressing insulin resistance and diabetes treatment

LGR signaling plays a crucial role in metabolic regulation by coordinating muscle-neuron-adipose tissue crosstalk. In response to a high-sugar diet, muscle-derived BMP signaling activates neuronal Bursicon, which stimulates insulin secretion and enhances adipose insulin sensitivity. This evolutionarily conserved pathway underscores LGR4 as a promising therapeutic target for insulin resistance and diabetes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).