Synthesis and Antimicrobial Screening of Some Thiazolidin-4-one Derivatives

ctive: Novel 2,3-diarylsubstituted-1,3-thiazolidin-4-one derivatives (IVa–IVm) were synthesized by reacting thioglycolic acid and Schiff bases (IIIa–IIIm) in the presence of 1,4-dioxane and ZnCl₂ using the conventional method. Methods: The structures of these compounds were confirmed by FT-IR, ¹H NMR, and mass spectrometry. The disc diffusion method was used to screen the antimicrobial activity of the newly synthesized compounds. Gram-negative (P. aeruginosa and E. coli) and Gram-positive (B. subtilis and S. aureus) bacterial strains were selected for antibacterial activity, using ciprofloxacin as a standard drug. Simultaneously, fungal strains (C. albicans and A. niger) were tested for antifungal activity using the standard drug fluconazole. Results and Discussion: The results of the study suggested that the synthesized derivatives showed good antibacterial and antifungal activity against all tested organisms. Conclusions: Compounds substituted with –OH, –Cl, –NO₂, and –OCH₃ groups on the aryl ring showed the maximum antibacterial and antifungal activity.